Human Calpain 1 Protein

Description

Human Calpain 1 Protein
Catalog number: B2014153
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: ≥1000 U/mg
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Calcium-activated neutral protease 1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Baudry M, Bi X. Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration Trends Neurosci. 2016 Apr;39(4):235-245.
2: Wang L, Zhang C, Sun S, Chen Y, Hu Y, Wang H, Liu M, Dong N, Wu Q. Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells Biochem J. 2019 Aug 28;476(16):2355-2369.
3: Sparatore B, Pedrazzi M, Garuti A, Franchi A, Averna M, Ballestrero A, De Tullio R. A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1260-1271.
4: Hsu CY, Gasc G, Raymond AA, Burlet-Schiltz O, Takahara H, Serre G, Mchin MC, Simon M. Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases J Invest Dermatol. 2017 Feb;137(2):422-429.
5: Shinkai-Ouchi F, Shindo M, Doi N, Hata S, Ono Y. Calpain-2 participates in the process of calpain-1 inactivation Biosci Rep. 2020 Nov 27;40(11):BSR20200552.
6: Miller DJ, Adams SE, Hallett MB, Allemann RK. Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future? Future Med Chem. 2013 Nov;5(17):2057-74.
7: Li RY, Zheng ZY, Li ZM, Heng JH, Zheng YQ, Deng DX, Xu XE, Liao LD, Lin W, Xu HY, Huang HC, Li EM, Xu LY. Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer Chem Biol Interact. 2022 Jul 1;361:109967.
8: Upla P, Marjom_ki V, Nissinen L, Nylund C, Waris M, Hyypi_ T, Heino J. Calpain 1 and 2 are required for RNA replication of echovirus 1 J Virol. 2008 Feb;82(3):1581-90.
9: Ruppert AM, Baud L, Rabbe N, Perez J, Duruisseaux M, Vieira T, Antoine M, Cadranel J, Wislez M. Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma Bull Cancer. 2019 Mar;106(3):179-188.
10: Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy Biochem J. 2021 Oct 15;478(19):3539-3553.

Products Related to Human Calpain 1 Protein can be found at Proteins