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Human C-C Chemokine Receptor Type 5

Original price was: $18,795.00.Current price is: $9,395.00.

Catalog Number: B2016509 (25 µg)
Human C-C Chemokine Receptor Type 5 is a high quality Human C-C Chemokine Receptor Type 5, also known as CCR5, which is a protein that is encoded by the CCR5 gene in humans. It is a cell surface receptor that belongs to the chemokine receptor family. CCR5 is primarily expressed on certain immune cells, such as T cells and macrophages, and plays a role in mediating the immune response by binding to specific chemokines. Additionally, CCR5 is known for its role as a co-receptor for the entry of certain strains of HIV into target cells, making it an important target for HIV research and therapy. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2016509 Categories: , Tag:

Product Description

Human C-C Chemokine Receptor Type 5
Catalog number: B2016509
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: N/A
Supplied as: N/A
Applications: a molecular tool for various biochemical applications
Storage: N/A
Keywords: CD195, CC-CKR-5, CKR5, CMKBR5
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Feng G, Bajpai G, Ma P, Koenig A, Bredemeyer A, Lokshina I, Lai L, Förster I, Leuschner F, Kreisel D, Lavine KJ. CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells Circulation. 2022 Mar 8;145(10):765-782.
3: Xie M, Lin Z, Ji X, Luo X, Zhang Z, Sun M, Chen X, Zhang B, Liang H, Liu D, Feng Y, Wang Y, Li Y, Liu B, Huang W, Xia L. FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2 J Hepatol. 2023 Jul;79(1):109-125.
4: Matsushima K, Yang D, Oppenheim JJ. Interleukin-8: An evolving chemokine Cytokine. 2022 May;153:155828.
5: Hamilton JD, Harel S, Swanson BN, Brian W, Chen Z, Rice MS, Amin N, Ardeleanu M, Radin A, Shumel B, Ruddy M, Patel N, Pirozzi G, Mannent L, Graham NMH. Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases Clin Exp Allergy. 2021 Jul;51(7):915-931.
6: Tian L, Xu B, Chen Y, Li Z, Wang J, Zhang J, Ma R, Cao S, Hu W, Chiocca EA, Kaur B, Caligiuri MA, Yu J. Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity Nat Cancer. 2022 Nov;3(11):1318-1335.
7: Park JH, Lee DH, Park MS, Jung YS, Hong JT. C-C chemokine receptor type 5 deficiency exacerbates alcoholic fatty liver disease through pro-inflammatory cytokines and chemokines-induced hepatic inflammation J Gastroenterol Hepatol. 2017 Jun;32(6):1258-1264.
8: Tanaka T, Suzuki H, Li G, Nanamiya R, Isoda Y, Okada Y, Kobayashi H, Yoshikawa T, Kaneko MK, Kato Y. Epitope Mapping of the Anti-Human CC Chemokine Receptor Type-2 Monoclonal Antibody (K036C2) Monoclon Antib Immunodiagn Immunother. 2022 Oct;41(5):285-289.
9: Festa BP, Siddiqi FH, Jimenez-Sanchez M, Rubinsztein DC. Microglial cytokines poison neuronal autophagy via CCR5, a druggable target Autophagy. 2024 Apr;20(4):949-951.
10: Kim J, Lee J, Kim HJ, Kameyama N, Nazarian R, Der E, Cohen S, Guttman-Yassky E, Putterman C, Krueger JG. Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets J Allergy Clin Immunol. 2021 Nov;148(5):1281-1292.

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Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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