Human BCL2L1 Protein

Description

Human BCL2L1 Protein
Catalog number: B2011634
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Bcl(X)L protein, bcl-x protein, bcl-XL protein, bcl-L-1 protein, bcl2l protein, bclX protein, Bcl2l1 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sillars-Hardebol AH, Carvalho B, Beliën JA, de Wit M, Delis-van Diemen PM, Tijssen M, van de Wiel MA, Pontén F, Fijneman RJ, Meijer GA. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain J Pathol. 2012 Feb;226(3):442-50.
2: He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity Nat Commun. 2020 Apr 24;11(1):1996.
3: Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, Vadai E, Dassa L, Shahar E, Condiotti R, Ben-Porath I, Krizhanovsky V. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Nat Commun. 2016 Apr 6;7:11190.
4: Dai Y, Shaikho EM, Perez J, Wilson CA, Liu LY, White MR, Farrell JJ, Chui DHK, Sebastiani P, Steinberg MH. BCL2L1 is associated with γ-globin gene expression Blood Adv. 2019 Oct 22;3(20):2995-3001.
5: Pawlak A, Henklewska M. The Role of Bcl-xL Protein Research in Veterinary Oncology Int J Mol Sci. 2020 Apr 4;21(7):2511.
6: Guo T, Gu C, Li B, Xu C. Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain Aging (Albany NY). 2021 Aug 5;13(15):19750-19759.
7: Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463 Aging (Albany NY). 2017 Mar 8;9(3):955-963.
8: Wyżewski Z, Świtlik W, Mielcarska MB, Gregorczyk-Zboroch KP. The Role of Bcl-xL Protein in Viral Infections Int J Mol Sci. 2021 Feb 16;22(4):1956.
9: Li M, Wang D, He J, Chen L, Li H. Bcl-X(L): A multifunctional anti-apoptotic protein Pharmacol Res. 2020 Jan;151:104547.
10: Lee EF, Fairlie WD. The Structural Biology of Bcl-x(L) Int J Mol Sci. 2019 May 7;20(9):2234.

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