Human ALAD Protein (Highly Pure)

Product Description

Human ALAD Protein (Highly Pure)
Catalog number: B2011571
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: ALAD protein (His tag), PBGS protein, ALADH protein, Delta-aminolevulinic acid dehydratase protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Jaffe EK. Porphobilinogen synthase: An equilibrium of different assemblies in human health Prog Mol Biol Transl Sci. 2020;169:85-104.
2: Qader A, Rehman K, Akash MSH. Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions Environ Sci Pollut Res Int. 2021 Sep;28(33):44818-44832.
3: Schmitt SM, Neslund-Dudas C, Shen M, Cui C, Mitra B, Dou QP. Involvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal α2 Subunits J Cell Biochem. 2016 Jan;117(1):144-51.
4: Bergdahl IA, Grubb A, Schütz A, Desnick RJ, Wetmur JG, Sassa S, Skerfving S. Lead binding to delta-aminolevulinic acid dehydratase (ALAD) in human erythrocytes Pharmacol Toxicol. 1997 Oct;81(4):153-8.
5: Andrei Nogara P, Batista Teixeira Rocha J. In Silico Studies of Mammalian δ-ALAD Interactions with Selenides and Selenoxides Mol Inform. 2018 Apr;37(4):e1700091.
6: Liu G, Sil D, Maio N, Tong WH, Bollinger JM Jr, Krebs C, Rouault TA. Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase Nat Commun. 2020 Dec 9;11(1):6310.
7: Kelada SN, Shelton E, Kaufmann RB, Khoury MJ. Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review Am J Epidemiol. 2001 Jul 1;154(1):1-13.
8: Gonick HC. Lead-binding proteins: a review J Toxicol. 2011;2011:686050.
9: Jaffe EK, Stith L. ALAD porphyria is a conformational disease Am J Hum Genet. 2007 Feb;80(2):329-37.
10: Shaik AP, Khan M, Jamil K. Phylogenetic analysis of ALAD and MGP genes related to lead toxicity Toxicol Ind Health. 2009 Jul;25(6):403-9.

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