Human AKT1 Protein (Highly Pure)

Product Description

Human AKT1 Protein (Highly Pure)
Catalog number: B2011570
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 500 µg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AKT1 protein (His tag), RAC-alpha serine/threonine-protein kinase protein, AKT protein, CWS6 protein, PKB protein, PKB-ALPHA protein, PRKBA protein, RAC protein, RAC-ALPHA protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science. 2005 Feb 18;307(5712):1098-101.
2: Cha Y, Kim T, Jeon J, Jang Y, Kim PB, Lopes C, Leblanc P, Cohen BM, Kim KS. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes Cell Rep. 2021 Dec 28;37(13):110155.
3: Xu Z, Xu M, Liu P, Zhang S, Shang R, Qiao Y, Che L, Ribback S, Cigliano A, Evert K, Pascale RM, Dombrowski F, Evert M, Chen X, Calvisi DF, Chen X. The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans Hepatology. 2019 Nov;70(5):1600-1613.
4: Balasuriya N, Davey NE, Johnson JL, Liu H, Biggar KK, Cantley LC, Li SS, O’Donoghue P. Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1) J Biol Chem. 2020 Jun 12;295(24):8120-8134.
5: Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med. 2005 Jan-Mar;9(1):59-71.
6: Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, Lu W, Lu Y. CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer Mol Cancer. 2019 Oct 17;18(1):144.
7: Deng T, Shen P, Li A, Zhang Z, Yang H, Deng X, Peng X, Hu Z, Tang Z, Liu J, Hou R, Liu Z, Fang W. CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer Theranostics. 2021 Jul 13;11(16):8112-8128.
8: Lai AN, Zhou R, Chen B, Guo L, Dai YY, Jia YP. MiR-149-3p can improve the osteogenic differentiation of human adipose-derived stem cells via targeting AKT1 Kaohsiung J Med Sci. 2021 Dec;37(12):1077-1088.
9: Jo EH, Ahn JS, Mo JS, Yoon JH, Ann EJ, Baek HJ, Lee HJ, Kim SH, Kim MY, Park HS. Akt1 phosphorylates Nicastrin to regulate its protein stability and activity J Neurochem. 2015 Sep;134(5):799-810.
10: Gu X, Wang Y, Wang M, Wang J, Li N. Computational investigation of imidazopyridine analogs as protein kinase B (Akt1) allosteric inhibitors by using 3D-QSAR, molecular docking and molecular dynamics simulations J Biomol Struct Dyn. 2021 Jan;39(1):63-78.

Products Related to Human AKT1 Protein (Highly Pure) can be found at Proteins