Human AHSP Protein (Highly Pure)

Product Description

Human AHSP Protein (Highly Pure)
Catalog number: B2011547
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20℃
Keywords: AHSP protein Purified recombinant Human AHSP protein, Erythroid associated factor protein, , Erythroid differentiation associated factor protein, Erythroid differentiation related factor protein, Alpha-hemoglobin stabilizing protein Alpha hemoglobin stabilizing protein , ERAF protein, EDRF protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Che Yaacob NS, Islam MA, Alsaleh H, Ibrahim IK, Hassan R. Alpha-hemoglobin-stabilizing protein (AHSP): a modulatory factor in β-thalassemia Int J Hematol. 2020 Mar;111(3):352-359.
2: Brillet T, Baudin-Creuza V, Vasseur C, Domingues-Hamdi E, Kiger L, Wajcman H, Pissard S, Marden MC. Alpha-hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSPV56G J Biol Chem. 2010 Jun 4;285(23):17986-92.
3: Walczak J, Camargo Johnson MD, Muthumalaiappan K. Stage Specific Expression Pattern of Alpha-Hemoglobin-Stabilizing-Protein (AHSP) Portrayed in Erythroblast Chronology Methods Protoc. 2020 Jun 30;3(3):46.
4: Mollan TL, Banerjee S, Wu G, Parker Siburt CJ, Tsai AL, Olson JS, Weiss MJ, Crumbliss AL, Alayash AI. α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide J Biol Chem. 2013 Feb 8;288(6):4288-98.
5: Domingues-Hamdi E, Vasseur C, Fournier JB, Marden MC, Wajcman H, Baudin-Creuza V. Role of α-globin H helix in the building of tetrameric human hemoglobin: interaction with α-hemoglobin stabilizing protein (AHSP) and heme molecule PLoS One. 2014 Nov 4;9(11):e111395.
6: Galstyan A, Markman JL, Shatalova ES, Chiechi A, Korman AJ, Patil R, Klymyshyn D, Tourtellotte WG, Israel LL, Braubach O, Ljubimov VA, Mashouf LA, Ramesh A, Grodzinski ZB, Penichet ML, Black KL, Holler E, Sun T, Ding H, Ljubimov AV, Ljubimova JY. Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy Nat Commun. 2019 Aug 28;10(1):3850.
7: Szolajska E, Chroboczek J. Faithful chaperones Cell Mol Life Sci. 2011 Oct;68(20):3307-22.
8: Ray R, Kalantri SA, Bhattacharjee S, Biswas A, Shahab A, Biswas S, Bhattacharyya M. Association of alpha hemoglobin-stabilizing protein (AHSP) gene mutation and disease severity among HbE-beta thalassemia patients Ann Hematol. 2019 Aug;98(8):1827-1834.
9: Dickson CF, Rich AM, D’Avigdor WM, Collins DA, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA. α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond J Biol Chem. 2013 Jul 5;288(27):19986-20001.
10: Emanuelli M, Cecati M, Sartini D, Stortoni P, Corradetti A, Giannubilo SR, Turi A, Tranquilli AL. Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage Cell Stress Chaperones. 2009 Mar;14(2):193-7.

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