Hexokinase from Saccharomyces cerevisiae

Product Description

Hexokinase from Saccharomyces cerevisiae
Catalog number: B2010460
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1000 units
Molecular Weight or Concentration: 110 kDa (dimer)
Supplied as: Lyophilized powder
Appearance: Powder
Applications: highly pure and high specific activity Hexokinase from Saccharomyces cerevisiae.
Storage: 2-8°C
Keywords: ATP:D-Hexose-6-phosphotransferase, Hexokinase from yeast
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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actions of TGF-β. Sci Signal. 2019 Dec 17;12(612):eaax4067.

2: Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso
M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N.
Hexokinase_2 is required for tumor initiation and maintenance and its systemic
deletion is therapeutic in mouse models of cancer. Cancer Cell. 2013 Aug
12;24(2):213-228.

3: Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, Pizzo P, Gori A,
Frezzato F, Chiara F, Trentin L, Bernardi P, Rasola A. Hexokinase 2 displacement
from mitochondria-associated membranes prompts Ca²⁺ -dependent death
of cancer cells. EMBO Rep. 2020 Jul 3;21(7):e49117.

4: Nawaz MH, Ferreira JC, Nedyalkova L, Zhu H, Carrasco-López C, Kirmizialtin S,
Rabeh WM. The catalytic inactivation of the N-half of human hexokinase 2 and
structural and biochemical characterization of its mitochondrial conformation.
Biosci Rep. 2018 Feb 21;38(1):BSR20171666.

5: Garcia SN, Guedes RC, Marques MM. Unlocking the Potential of HK2 in Cancer
Metabolism and Therapeutics. Curr Med Chem. 2019;26(41):7285-7322.

6: Sun J, Zhu F, Chen H, Yao M, Zhu G, Zhang Y, Wang Q, Shen Z. Identification
and subcellular localisation of hexokinase-2 in Nosema bombycis. Folia Parasitol
(Praha). 2020 Sep 21;67:2020.023.

7: Li J, Chen G, Zhang J, Shen H, Kang J, Feng P, Xie Q, Hu Z. Suppression of a
hexokinase gene, SlHXK1, leads to accelerated leaf senescence and stunted plant
growth in tomato. Plant Sci. 2020 Sep;298:110544.

8: Aljamal JA, Badawneh M. In vitro inhibition of human erythrocyte hexokinase
by various hyperglycemic drugs. J Biochem Mol Toxicol. 2017 Aug;31(8).

9: Krasnov GS, Dmitriev AA, Lakunina VA, Kirpiy AA, Kudryavtseva AV. Targeting
VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer
therapy. Expert Opin Ther Targets. 2013 Oct;17(10):1221-33.
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paper assay for determination of hexokinase activity and affinity for
glucose-6-phosphate. J Appl Physiol (1985). 2019 Sep 1;127(3):661-667.

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