GRK5 Protein Human Active


Catalog Number: B2014105 (10 μg)
GRK5 Protein Human Active is a high quality recombinant, full length, human GRK5, for use in Kinase Assays. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2014105 Categories: , Tag:


GRK5 Protein Human Active
Catalog number: B2014105
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 μg
Molecular Weight or Concentration: 71.6 kDa
Supplied as: N/A
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: GRK5 Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Pfleger J, Gresham K, Koch WJ. G protein-coupled receptor kinases astherapeutic targets in the heart Nat Rev Cardiol. 2019 Oct;16(10):612-622.
2: Laudette M, Formoso K, Lezoualc’h F. GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure Cells. 2021 Jan 14;10(1):154.
3: Kunapuli P, Onorato JJ, Hosey MM, Benovic JL. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5 J Biol Chem. 1994 Jan 14;269(2):1099-105.
4: Lee JH, Seo HW, Ryu JY, Lim CJ, Yi KY, Oh KS, Lee BH. KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure Biomol Ther (Seoul). 2020 Sep 1;28(5):482-489.
5: Downes K, Zhao X, Gleadall NS, McKinney H, Kempster C, Batista J, Thomas PL, Cooper M, Michael JV, Kreuzhuber R, Wedderburn K, Waller K, Varney B, Verdier H, Kriek N, Ashford SE, Stirrups KE, Dunster JL, McKenzie SE, Ouwehand WH, Gibbins JM, Yang J, Astle WJ, Ma P. G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1 Blood Adv. 2022 Apr 12;6(7):2319-2330.
6: Zhang Y, Shen GL, Shangguan LJ, Yu Y, He ML. Involvement of NFB signaling in mediating the effects of GRK5 on neural stem cells Brain Res. 2015 May 22;1608:31-9.
7: Yang Y, Wu JJ, Cheng CD, Bao DJ, Dong YF, Li DX, Niu WX, Zhou CX, Niu CS. G-protein-coupled receptor kinase-5 promotes glioblastoma progression by targeting the nuclear factor kappa B pathway Am J Transl Res. 2018 Nov 15;10(11):3370-3384. eCollection 2018.
8: Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634.
9: Tran TM, Jorgensen R, Clark RB. Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5 Biochemistry. 2007 Dec 18;46(50):14438-49.
10: Adzika GK, Hou H, Adekunle AO, Rizvi R, Adzraku SY, Li K, Deng QM, Mprah R, Ndzie Noah ML, Adu-Amankwaah J, Machuki JO, Shang W, Ma T, Koda S, Ma X, Sun H. Amlexanox and Forskolin Prevents Isoproterenol-Induced Cardiomyopathy by Subduing Cardiomyocyte Hypertrophy and Maladaptive Inflammatory Responses Front Cell Dev Biol. 2021 Sep 24;9:719351.

Products Related to GRK5 Protein Human Active can be found at Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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