Ganglioside GD2 Antibody

Description

Ganglioside GD2 Antibody
Catalog number: B2010970
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: na
Supplied as: Solution
Applications: molecular tool for various immunological applications
Storage: -20°C
Keywords: Anti-GD2 Monoclonal Antibody, Anti-GD2 Antibody
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Cheung IY, Cheung NV, Modak S, Mauguen A, Feng Y, Basu E, Roberts SS, Ragupathi G, Kushner BH. Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression J Clin Oncol. 2021 Jan 20;39(3):215-226.
2: Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, Shimada H, Grupp SA, Seeger R, Reynolds CP, Buxton A, Reisfeld RA, Gillies SD, Cohn SL, Maris JM, Sondel PM; Children’s Oncology Group. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma N Engl J Med. 2010 Sep 30;363(14):1324-34.
3: Sait S, Modak S. Anti-GD2 immunotherapy for neuroblastoma Expert Rev Anticancer Ther. 2017 Oct;17(10):889-904.
4: Zhu W, Mao X, Wang W, Chen Y, Li D, Li H, Dou P. Anti-ganglioside GD2 monoclonal antibody synergizes with cisplatin to induce endoplasmic reticulum-associated apoptosis in osteosarcoma cells Pharmazie. 2018 Feb 1;73(2):80-86.
5: Yesmin F, Bhuiyan RH, Ohmi Y, Yamamoto S, Kaneko K, Ohkawa Y, Zhang P, Hamamura K, Cheung NV, Kotani N, Honke K, Okajima T, Kambe M, Tajima O, Furukawa K, Furukawa K. Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins Int J Mol Sci. 2021 Dec 31;23(1):423.
6: Horwacik I, Golik P, Grudnik P, Kolinski M, Zdzalik M, Rokita H, Dubin G. Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody Mol Cell Proteomics. 2015 Oct;14(10):2577-90.
7: Durbas M, Pabisz P, Wawak K, Wiśniewska A, Boratyn E, Nowak I, Horwacik I, Woźnicka O, Rokita H. GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells Apoptosis. 2018 Oct;23(9-10):492-511.
8: Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, Barrett DM, Grupp SA, Milone MC. High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model Cancer Immunol Res. 2018 Jan;6(1):36-46.
9: Roth M, Linkowski M, Tarim J, Piperdi S, Sowers R, Geller D, Gill J, Gorlick R. Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma Cancer. 2014 Feb 15;120(4):548-54.
10: Navid F, Santana VM, Barfield RC. Anti-GD2 antibody therapy for GD2-expressing tumors Curr Cancer Drug Targets. 2010 Mar;10(2):200-9.

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