Fluorogenic Caspase 3 (Apopain) Substrate 1r-z

Product Description

Fluorogenic Caspase 3 (Apopain) Substrate 1r-z
Catalog number: B2011410
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 1515.5 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Caspase 3 (Apopain) Substrate 1r-z, fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Pérez-López AM, Soria-Gila ML, Marsden ER, Lilienkampf A, Bradley M. Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells PLoS One. 2016 May 11;11(5):e0153209.
2: Mackay M, Pérez-López AM, Bradley M, Lilienkampf A. Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates Mol Biosyst. 2016 Mar;12(3):693-6.
3: Xiong C, Lu W, Zhang R, Tian M, Tong W, Gelovani J, Li C. Cell-permeable [99mTc(CO3)]-labeled fluorogenic caspase 3 substrate for dual-modality detection of apoptosis Chemistry. 2009 Sep 14;15(36):8979-84.
4: Gilbert K, Godbout R, Rousseau G. Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction J Vis Exp. 2016 Jan 12;(107):e53207.
5: Peterson QP, Goode DR, West DC, Botham RC, Hergenrother PJ. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis Nat Protoc. 2010 Feb;5(2):294-302.
6: Fan J, Cheney PP, Bloch S, Xu B, Liang K, Odonkor CA, Edwards WB, Basak S, Mintz R, Biswas P, Achilefu S. Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3 Curr Anal Chem. 2021;17(8):1182-1193.
7: Lozanov V, Ivanov IP, Benkova B, Mitev V. Peptide substrate for caspase-3 with 2-aminoacridone as reporting group Amino Acids. 2009 Mar;36(3):581-6.
8: Kitevska T, Roberts SJ, Pantaki-Eimany D, Boyd SE, Scott FL, Hawkins CJ. Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate Biosci Rep. 2014 Apr 1;34(2):e00100.
9: Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells Cell Death Differ. 2019 Dec;26(12):2695-2709.
10: Fuente-Garcia C, Sentandreu E, Aldai N, Sentandreu MA. Optimization of a fluorogenic assay to determine caspase 3/7 activity in meat extracts Food Sci Technol Int. 2022 Mar;28(2):128-134.

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