Factor VIIa Substrate

Product Description

Factor VIIa Substrate
Catalog number: B2013011
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2 mg
Molecular Weight or Concentration: 644.8 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: MeSO2-Cha-Abu-Arg-AFC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Birkle F, Morrissey JH. A serine loop in tissue factor mediates substrate selectivity by the tissue factor-factor VIIa complex J Thromb Haemost. 2021 Jan;19(1):75-84.
2: Gajsiewicz JM, Morrissey JH. Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa Semin Thromb Hemost. 2015 Oct;41(7):682-90.
3: Persson E, Olsen OH. Current status on tissue factor activation of factor VIIa Thromb Res. 2010 Apr;125 Suppl 1:S11-2.
4: Sichler K, Banner DW, D’Arcy A, Hopfner KP, Huber R, Bode W, Kresse GB, Kopetzki E, Brandstetter H. Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions J Mol Biol. 2002 Sep 20;322(3):591-603.
5: Shobe J, Dickinson CD, Edgington TS, Ruf W. Macromolecular substrate affinity for the tissue factor-factor_VIIa complex is independent of scissile bond docking J Biol Chem. 1999 Aug 20;274(34):24171-5.
6: Butenas S, Lawson JH, Kalafatis M, Mann KG. Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa Biochemistry. 1994 Mar 22;33(11):3449-56.
7: Ruf W, Shobe J, Rao SM, Dickinson CD, Olson A, Edgington TS. Importance of factor_VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain Biochemistry. 1999 Feb 16;38(7):1957-66.
8: Higashi S, Nishimura H, Fujii S, Takada K, Iwanaga S. Tissue factor potentiates the factor_VIIa-catalyzed hydrolysis of an ester substrate J Biol Chem. 1992 Sep 5;267(25):17990-6.
9: Larsen KS, Ostergaard H, Olsen OH, Bjelke JR, Ruf W, Petersen LC. Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2 J Biol Chem. 2010 Jun 25;285(26):19959-66.
10: Bjelke JR, Persson E, Rasmussen HB, Kragelund BB, Olsen OH. A loop of coagulation factor VIIa influencing macromolecular substrate specificity FEBS Lett. 2007 Jan 9;581(1):71-6.

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