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Epiregulin (Human, Recombinant)

$595.00 $395.00

Catalog Number: B2010300 (10 ug)
Epiregulin (Human, Recombinant) is a high quality research product used as highly pure Epiregulin (Human, Recombinant) expressed in E. coli. This protein acts as a growth regulator and member of the epidermal growth factor (EGF) family with tumor growth inhibitory effects in human epidermoid carcinoma HeLa cells. Custom bulk orders of this product are available upon request.

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SKU: B2010300 Categories: , ,

Description

Epiregulin (Human, Recombinant)
Catalog number: B2010300
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Epiregulin (Human, Recombinant) expressed in E. coli. This protein acts as a growth regulator and member of the epidermal growth factor (EGF) family with tumor growth inhibitory effects in human epidermoid carcinoma HeLa cells.
Storage: -20C
Keywords: rHuEpiregulin; EREG; EPR
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Verma V, Khoury S, Parisien M, Cho C, Maixner W, Martin LJ, Diatchenko L. The
dichotomous role of epiregulin in pain. Pain. 2020 May;161(5):1052-1064.

2: Cui D, Xiao J, Zhou Y, Zhou X, Liu Y, Peng Y, Yu Y, Li H, Zhou X, Yuan Q, Wan
M, Zheng L. Epiregulin enhances odontoblastic differentiation of dental pulp
stem cells via activating MAPK signalling pathway. Cell Prolif. 2019
Nov;52(6):e12680.

3: Cui X, Wang H, Li Y, Chen T, Liu S, Yan Q. Epiregulin promotes trophoblast
epithelial-mesenchymal transition through poFUT1 and O-fucosylation by poFUT1 on
uPA. Cell Prolif. 2020 Feb;53(2):e12745.

4: Wang Y, Jing Y, Ding L, Zhang X, Song Y, Chen S, Zhao X, Huang X, Pu Y, Wang
Z, Ni Y, Hu Q. Epiregulin reprograms cancer-associated fibroblasts and
facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway. J Exp
Clin Cancer Res. 2019 Jun 24;38(1):274.

5: Riese DJ 2nd, Cullum RL. Epiregulin: roles in normal physiology and cancer.
Semin Cell Dev Biol. 2014 Apr;28:49-56.

6: Yang WW, Yang LQ, Zhao F, Chen CW, Xu LH, Fu J, Li SL, Ge XY. Epiregulin
Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma. Theranostics.
2017 Aug 23;7(15):3700-3714.

7: Xia Q, Zhou Y, Yong H, Wang X, Zhao W, Ding G, Zhu J, Li X, Feng Z, Wang B.
Elevated epiregulin expression predicts poor prognosis in gastric cancer. Pathol
Res Pract. 2019 May;215(5):873-879.

8: Kuramochi H, Nakajima GO, Hayashi K, Araida T, Yamamoto M.
Amphiregulin/epiregulin mRNA Expression and Primary Tumor Location in
Colorectal Cancer. Anticancer Res. 2019 Sep;39(9):4729-4736.

9: Sunaga N, Kaira K. Epi_regulin as a therapeutic target in non-small-cell lung
cancer. Lung Cancer (Auckl). 2015 Oct 12;6:91-98.
10: Roskoski R Jr. The ErbB/HER family of protein-tyrosine kinases and cancer.
Pharmacol Res. 2014 Jan;79:34-74.

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