Beta Defensin-2 (Human, Recombinant)

Product Description

Beta Defensin-2 (Human, Recombinant)
Catalog number: B2010344
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Beta Defensin-2 (Human, Recombinant) expressed in E. coli. This protein acts as an anti-microbial peptide that participates in the response to microbial invasion.
Storage: -20C
Keywords: rHuBD-2; DEFB2
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kolbinger F, Loesche C, Valentin MA, Jiang X, Cheng Y, Jarvis P, Peters T,
Calonder C, Bruin G, Polus F, Aigner B, Lee DM, Bodenlenz M, Sinner F, Pieber
TR, Patel DD. β-Defensin 2 is a responsive biomarker of IL-17A-driven skin
pathology in patients with psoriasis. J Allergy Clin Immunol. 2017
Mar;139(3):923-932.e8.

2: Koeninger L, Armbruster NS, Brinch KS, Kjaerulf S, Andersen B, Langnau C,
Autenrieth SE, Schneidawind D, Stange EF, Malek NP, Nordkild P, Jensen BAH,
Wehkamp J. Human β-Defensin 2 Mediated Immune Modulation as Treatment for
Experimental Colitis. Front Immunol. 2020 Jan 31;11:93.

3: Ju J, Tan R, Zhong Y, Peng L, Pan Y. Effect of icariin on early
β–defensin–2 and T cell subsets in rats after tracheotomy. Zhong
Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jan 28;45(1):1-7. English, Chinese.

4: Corebima BIRV, Rohsiswatmo R, Gayatri P, Patole S. Fecal human β-defensin-2
(hBD-2) levels and gut microbiota patterns in preterm neonates with different
feeding patterns. Iran J Microbiol. 2019 Apr;11(2):151-159.

5: Järvå M, Phan TK, Lay FT, Caria S, Kvansakul M, Hulett MD. Human β-defensin 2
kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-
mediated membrane permeabilization. Sci Adv. 2018 Jul 25;4(7):eaat0979.

6: Huang J, Qi Y, Wang A, Huang C, Liu X, Yang X, Li L, Zhou R. Porcine
β-defensin 2 inhibits proliferation of pseudorabies virus in vitro and in
transgenic mice. Virol J. 2020 Feb 3;17(1):18.

7: Kotani H, Koshizuka T, Matsubara K, Nishiyama K, Sugiyama T, Suzutani T.
Relationship Between Human β-Defensin 2 and the Vaginal Environment. Jpn J
Infect Dis. 2020 May 22;73(3):214-220.
8: Cohen JN, Bowman S, Laszik ZG, North JP. Clinicopathologic overlap of
psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T
helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic
psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-
associated dermatitis. J Am Acad Dermatol. 2020 Feb;82(2):430-439.

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