Anti-TSHR Monoclonal Antibodies

Description

Anti-TSHR Monoclonal Antibodies
Catalog number: B2010393
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 150 kDa
Supplied as: Solution
Appearance: Clear Solution
Applications: Five different Mouse Monoclonal Antibodies specific to human TSH Receptor (TSHR). These antibodies were validated in the detection of TSHR in many applications including WB, IP nd other immunoassays. Available in biotinylated version.
Storage: -20C
Keywords: antibody to human TSHR, anti human TSHR, hTSHR antibody
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Woeller CF, Roztocil E, Hammond C, Feldon SE. TSHR Signaling Stimulates
Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid
Eye Disease Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2019 Oct
1;60(13):4336-4345.

2: Diana T, Olivo PD, Kahaly GJ. Thyrotropin Receptor Blocking Antibodies. Horm
Metab Res. 2018 Dec;50(12):853-862.

3: Furmaniak J, Sanders J, Núñez Miguel R, Rees Smith B. Mechanisms of Action of
TSHR Autoantibodies. Horm Metab Res. 2015 Sep;47(10):735-52.

4: Pujol-Borrell R, Álvarez-Sierra D, Jaraquemada D, Marín-Sánchez A, Colobran
R. Central Tolerance Mechanisms to TSHR in Graves’ Disease: Contributions to
Understand the Genetic Association. Horm Metab Res. 2018 Dec;50(12):863-870.

5: Holthoff HP, Uhland K, Kovacs GL, Reimann A, Adler K, Wenhart C, Ungerer M.
Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves’ disease.
J Endocrinol. 2020 Aug 1;246(2):135-147.

6: Qu M, Wan S, Ren B, Wu H, Liu L, Shen H. Association between TSHR gene
methylation and papillary thyroid cancer: a meta-analysis. Endocrine. 2020
Sep;69(3):508-515.

7: Liu T, Men Q, Su X, Chen W, Zou L, Li Q, Song M, Ouyang D, Chen Y, Li Z, Fu
X, Yang A. Downregulated expression of TSHR is associated with distant
metastasis in thyroid cancer. Oncol Lett. 2017 Dec;14(6):7506-7512.

8: Fang Y, Sun F, Zhang RJ, Zhang CR, Yan CY, Zhou Z, Zhang QY, Li L, Ying YX,
Zhao SX, Liang J, Song HD. Mutation screening of the TSHR gene in 220 Chinese
patients with congenital hypothyroidism. Clin Chim Acta. 2019 Oct;497:147-152.

9: Zhou L, Wu K, Zhang L, Gao L, Chen S. Liver-specific deletion of TSHR
inhibits hepatic lipid accumulation in mice. Biochem Biophys Res Commun. 2018
Feb 26;497(1):39-45.
10: Huth S, Jaeschke H, Schaarschmidt J, Paschke R. Controversial constitutive
TSHR activity: patients, physiology, and in vitro characterization. Horm Metab
Res. 2014 Jun;46(7):453-61.

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