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ACPA, Monoclonal Antibody

Original price was: $3,195.00.Current price is: $1,595.00.

Catalog Number: B2026946 (100 ug)
ACPA, Monoclonal Antibody is a recombinant chimeric antibody derived from rheumatoid arthritis patients that specifically recognizes multiple citrullinated proteins and peptides, such as CCP2 and citrullinated collagen type 2. Custom bulk amounts of this product are available upon request.

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SKU: B2026946 Category: Tag:

Product Description

5/5 - (1 vote)

ACPA, Monoclonal Antibody
Catalog number: B2026946
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: NA
Supplied as: Solution
Storage: −20°C
Keywords: Citrullinated epitopes of COL2, Collagen alpha-1(II) chain, COL2A1, type II collagen, CII1, Citrullinated epitopes of ENO1, MPB

References:
1. He Y, Ge C, Moreno-Giro A, et al. A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis. Nat Commun. 2023;14(1):691.
2. Steen J, Forsstrom B, Sahlstrom P, et al. Recognition of acetylated histones by ACPA subsets: a novel link between ACPA and neutrophil extracellular traps. Arthritis Rheumatol. 2023.
3. Kudze T, Sahlstrom P, Steen J, et al. Tenosynovitis, Pain, and Bone Loss Induced by Patient-Derived Anti-Citrullinated Protein Antibodies. Arthritis Rheumatol. 2023;75(4):521-532.
4. Uysal H, Amara K, He Y, et al. Structure and function of anti-citrullinated protein antibodies. Ann Rheum Dis. 2022.
5. Grönwall C, Amara K, Hardt U, et al. Autoreactivity to native and citrullinated histones in rheumatoid arthritis. Ann Rheum Dis. 2021.
6. Chirivi RGC, van Rosmalen JWG, van der Linden M, et al. Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases. Cell Mol Immunol. 2021;18:1528-1544.
7. Lloyd KA, Wigerblad G, Sahlström P, et al. Differential contribution of ACPA fine-specificities to osteoclastogenesis, bone loss and joint pain. Ann Rheum Dis. 2016;75(6):1135-41.
8. Krishnamurthy A, Joshua V, Haj-Zaneh AH, et al. Identification of a novel chemokine-like function of anti-citrullinated protein antibodies. Ann Rheum Dis. 2016;75(4):755-62.
9. Amara K, Steen J, Murray F, et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a limited specificity and exhibit pro-inflammatory functions. Ann Rheum Dis. 2013;72(7):1221-7.
10. Harre U, Georgess D, Bang H, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012;122(5):1791-802.
ACPA, Monoclonal Antibody (Clone E4NG)

Products Related to ACPA, Monoclonal Antibody can be found at Antibodies

Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
5/5 - (1 vote)

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