α-Conotoxin SI

Product Description

α-Conotoxin SI
Catalog number: MDP0613
CAS Number: 82989-21-7
Sequence: Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys2-Cys7 and Cys3-Cys13)
Amount: 500 ug
Molecular Weight: 1353.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Camilloni C, Cavalli A, Vendruscolo M. Replica-Averaged Metadynamics J Chem Theory Comput. 2013 Dec 10;9(12):5610-7.
2: Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW. Solution structure of alpha-conotoxin SI FEBS Lett. 2000 Jul 7;476(3):287-95.
3: Zafaralla GC, Ramilo C, Gray WR, Karlstrom R, Olivera BM, Cruz LJ. Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI Biochemistry. 1988 Sep 6;27(18):7102-5.
4: Wiere S, Sugai C, Espiritu MJ, Aurelio VP, Reyes CD, Yuzon N, Whittal RM, Tytgat J, Peigneur S, Bingham JP. Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus Int J Mol Sci. 2022 Oct 11;23(20):12096.
5: Hargittai B, Solé NA, Groebe DR, Abramson SN, Barany G. Chemical syntheses and biological activities of lactam analogues of alpha-conotoxin SI J Med Chem. 2000 Dec 14;43(25):4787-92.
6: Konno H, Yasumiishi H, Aoki R, Nitanai I, Yano S. Detection of Thiol Functionality and Disulfide Bond Formation by Polyoxometalate ACS Comb Sci. 2020 Dec 14;22(12):745-749.
7: Shigeri Y, Inazumi S, Hagihara Y, Yasuda A, Kawasaki H, Arakawa R, Nakata M. Desorption/ionization efficiency of peptides containing disulfide bonds in matrix-assisted laser desorption/ionization mass spectrometry Anal Sci. 2012;28(3):295-9.
8: Jackson HC, Scheideler MA. Behavioural and anticonvulsant effects of Ca2+ channel toxins in DBA/2 mice Psychopharmacology (Berl). 1996 Jul;126(1):85-90.
9: Ma D, Sun J, Shen S, Chen H, Xu W, Wang Y, Song C, Shi T, Huo S. Deprotection of S-Acetamidomethyl and 1,3-Thiazolidine-4-Carbonyl Protecting Groups from Cysteine Side Chains in Peptides by trans-[PtX(2)(CN)(4)](2-): One-Pot Regioselective Synthesis of Disulfide Bonds J Org Chem. 2022 Jan 21;87(2):1470-1476.
10: Hargittai B, Barany G. Controlled syntheses of natural and disulfide-mispaired regioisomers of alpha-conotoxin SI J Pept Res. 1999 Dec;54(6):468-79.

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