5-chloro-2′-deoxyuridine (Highly Pure)

Product Description

5-chloro-2′-deoxyuridine (Highly Pure)
Catalog number: B2012300
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 262.6 g/mol
Supplied as: Crystals
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: Chlorodeoxyuridine, CldU
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Yamada K, Semba R, Ding X, Ma N, Nagahama M. Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2′-deoxyuridine and 5-chloro-2′-deoxyuridine J Histochem Cytochem. 2005 Nov;53(11):1365-70.
3: Hale JT, Bigelow JC, Mathews LA, McCormack JJ. Analytical and pharmacokinetic studies with 5-chloro-2′-deoxycytidine Biochem Pharmacol. 2002 Nov 15;64(10):1493-502.
4: Hoheisel JD, Lehrach H. Quantitative measurements on the duplex stability of 2,6-diaminopurine and 5-chloro-uracil nucleotides using enzymatically synthesized oligomers FEBS Lett. 1990 Nov 12;274(1-2):103-6.
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6: Pivazyan AD, Birks EM, Wood TG, Lin TS, Prusoff WH. Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine Biochem Pharmacol. 1992 Sep 1;44(5):947-53.
7: Smee DF, Humphreys DE, Hurst BL, Barnard DL. Antiviral activities and phosphorylation of 5-halo-2′-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus Antivir Chem Chemother. 2008;19(1):15-24.
8: Liu W. Single Molecular Resolution to Monitor DNA Replication Fork Dynamics upon Stress by DNA Fiber Assay Bio Protoc. 2021 Dec 20;11(24):e4269.
9: Eremeeva E, Abramov M, Marlière P, Herdewijn P. The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair Org Biomol Chem. 2016 Dec 20;15(1):168-176.
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