VEGFR2/Flk-1/KDR Human

Description

VEGFR2/Flk-1/KDR Human
Catalog number: B2013722
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 μg
Molecular Weight or Concentration: 84.1 kDa
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: CD309, VEGFR, kinase insert domain receptor
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zhou W, Liu K, Zeng L, He J, Gao X, Gu X, Chen X, Jing Li J, Wang M, Wu D, Cai Z, Claesson-Welsh L, Ju R, Wang J, Zhang F, Chen Y. Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension Circulation. 2022 Dec 13;146(24):1855-1881.
2: Eguchi R, Kawabe JI, Wakabayashi I. VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling J Vasc Res. 2022;59(2):78-89.
3: Sun J, Huang W, Yang SF, Zhang XP, Yu Q, Zhang ZQ, Yao J, Li KR, Jiang Q, Cao C. Gi1 and Gi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis Theranostics. 2018 Sep 9;8(17):4695-4709.
4: Zhou HJ, Xu Z, Wang Z, Zhang H, Zhuang ZW, Simons M, Min W. SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis Nat Commun. 2018 Aug 17;9(1):3303.
5: Liu K, Ren T, Huang Y, Sun K, Bao X, Wang S, Zheng B, Guo W. Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma Cell Death Dis. 2017 Aug 24;8(8):e3015.
6: Zhong M, Li N, Qiu X, Ye Y, Chen H, Hua J, Yin P, Zhuang G. TIPE regulates VEGFR2 expression and promotes angiogenesis in colorectal cancer Int J Biol Sci. 2020 Jan 1;16(2):272-283.
7: Mateluna C, Torres P, Rodriguez-Pea M, Silva P, Matthies DJ, Criollo A, Bikker FJ, Bolscher JGM, Wilson CAM, Zapata-Torres G, Torres VA. Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells Biochem Pharmacol. 2022 Jul;201:115079.
8: Zhu P, Hu C, Hui K, Jiang X. The role and significance of VEGFR2(+) regulatory T cells in tumor immunity Onco Targets Ther. 2017 Sep 1;10:4315-4319.
9: Prasad CB, Singh D, Pandey LK, Pradhan S, Singh S, Narayan G. VEGFa/VEGFR2 autocrine and paracrine signaling promotes cervical carcinogenesis via _-catenin and snail Int J Biochem Cell Biol. 2022 Jan;142:106122.
10: Cho HD, Nhn NTT, Zhou C, Tu K, Nguyen T, Sarich NA, Yamada KH. KIF13B mediates VEGFR2 recycling to modulate vascular permeability Cell Mol Life Sci. 2023 Mar 16;80(4):91.

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