Thrombin Substrate

Product Description

Thrombin Substrate
Catalog number: B2011508
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 625.6 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: H-D-Phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride, H-D-Phe-Pip-Arg-pNA . 2 HCl
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lau A, Berry LR, Mitchell LG, Chan AK. Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro Thromb Res. 2007;119(6):667-77.
2: Sloan IG, Firkin BG. Effects of EACA on thrombin generation as measured by the chromagen S2238 Thromb Res. 1986 Dec 15;44(6):761-9.
3: Lan Z, Zhang Y, Sun Y, Wang L, Huang Y, Cao H, Wang S, Meng J. Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS Front Pharmacol. 2021 Dec 10;12:769021.
4: Johnson LA, de Jersey J, Masci PP, Zhao KN, Bennett NC, Dimeski G, Grant M, Lavin MF. Progress Curve Analysis of the one stage chromogenic assay for ecarin Anal Biochem. 2020 Nov 1;608:113907.
5: Meh DA, Siebenlist KR, Mosesson MW. Identification and characterization of the thrombin binding sites on fibrin J Biol Chem. 1996 Sep 20;271(38):23121-5.
6: Kolodziejczyk-Czepas J, Sieradzka M, Moniuszko-Szajwaj B, Pecio Ł, Ponczek MB, Nowak P, Stochmal A. Bufadienolides from Kalanchoe daigremontiana as thrombin inhibitors-In vitro and in silico study Int J Biol Macromol. 2017 Jun;99:141-150.
7: Kolodziejczyk-Czepas J, Ponczek M, Sady-Janczak M, Pilarski R, Bukowska B. Extracts from Uncaria tomentosa as antiplatelet agents and thrombin inhibitors – The in vitro and in silico study J Ethnopharmacol. 2021 Mar 1;267:113494.
8: Du S, Harenberg J, Krämer S, Krämer R, Wehling M, Weiss C. Measurement of Non-Vitamin K Antagonist Oral Anticoagulants in Patient Plasma Using Heptest-STAT Coagulation Method Ther Drug Monit. 2015 Jun;37(3):375-80.
9: Ghigliotti G, Waissbluth AR, Speidel C, Abendschein DR, Eisenberg PR. Prolonged activation of prothrombin on the vascular wall after arterial injury Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):250-7.
10: Larsen ML, Abildgaard U, Teien AN, Gjesdal K. Assay of plasma heparin using thrombin and the chromogenic substrate H-D-Phe-Pip-Arg-pNA (S-2238) Thromb Res. 1978 Aug;13(2):285-8.

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