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Thrombin from Human Plasma (High Activity)

$495.00

Catalog Number: B2010413 (100 Units)
Thrombin from Human Plasma (High Activity) is a high quality research product used as very high specific activity Thrombin from human plasma. Thrombin is a serin protease that converts soluble fibrinogen into insoluble fibrin during the clotting process. Activity is measured using the NIH Thrombin Reference Standard. Custom bulk orders of this product are available upon request.
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SKU: B2010413 Categories: ,

Description

Thrombin from Human Plasma (High Activity)
Catalog number: B2010413
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 Units
Molecular Weight or Concentration: ≥2,000 NIH units/mg protein
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: very high specific activity Thrombin from human plasma. Thrombin is a serin protease that converts soluble fibrinogen into insoluble fibrin during the clotting process. Activity is measured using the NIH Thrombin Reference Standard.
Storage: -20C
Keywords: Factor Iia, Bovine Thrombin, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hemker HC, Al Dieri R, Béguin S. Thrombin generation assays: accruing
clinical relevance. Curr Opin Hematol. 2004 May;11(3):170-5.

2: Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb
Hemost. 2006 Apr;32 Suppl 1:16-31.

3: Xiao J , Salsbury FR . Na+-binding modes involved in thrombin’s
allosteric response as revealed by molecular dynamics simulations, correlation
networks and Markov modeling. Phys Chem Chem Phys. 2019 Feb 20;21(8):4320-4330.

4: Li X, Wu Y, Niu J, Jiang D, Xiao D, Zhou C. One-step sensitive thrombin
detection based on a nanofibrous sensing platform. J Mater Chem B. 2019 Sep
14;7(34):5161-5169.

5: Chan B, Merchan JR, Kale S, Sukhatme VP. Antiangiogenic property of human
thrombin. Microvasc Res. 2003 Jul;66(1):1-14.

6: Gordon EA, Fenton JW 2nd, Carney DH. Thrombin-receptor occupancy initiates a
transient increase in cAMP levels in mitogenically responsive hamster (NIL)
fibroblasts. Ann N Y Acad Sci. 1986;485:249-63.

7: Festoff BW, Smirnova IV, Ma J, Citron BA. Thrombin, its receptor and protease
nexin I, its potent serpin, in the nervous system. Semin Thromb Hemost.
1996;22(3):267-71.

8: Anderson CD, Bowman LJ, Chapman WC. Topical use of recombinant human thrombin
for operative hemostasis. Expert Opin Biol Ther. 2009 Jan;9(1):133-7.

9: Tanaka KA, Levy JH. Regulation of thrombin activity–pharmacologic and
structural aspects. Hematol Oncol Clin North Am. 2007 Feb;21(1):33-50.

10: Leung LL, Myles T, Nishimura T, Song JJ, Robinson WH. Regulation of tissue
inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Mol Immunol.
2008 Oct;45(16):4080-3.
11: Xu H, Cui H, Yin Z, Wei G, Liao F, Shu Q, Ma G, Cheng L, Hong N, Xiong J,
Fan H. Highly sensitive host-guest mode homogenous electrochemical thrombin
signal amplification aptasensor based on tetraferrocene label.
Bioelectrochemistry. 2020 Aug;134:107522.

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