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Skeletal Troponin I

$895.00

Catalog Number: B2012213 (100 ug)
Skeletal Troponin I is a high quality human Skeletal Troponin I (sTnI) purified from Human Skeletal Muscle. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Description

Skeletal Troponin I
Catalog number: B2012213
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 21 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: sTnI, sTn-I, muscle Tn-I, TnI
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Katrukha IA. Human cardiac troponin complex. Structure and functions Biochemistry (Mosc). 2013 Dec;78(13):1447-65.
2: De Matteis A, dell’Aquila M, Maiese A, Frati P, La Russa R, Bolino G, Fineschi V. The Troponin-I fast skeletal muscle is reliable marker for the determination of vitality in the suicide hanging Forensic Sci Int. 2019 Aug;301:284-288.
3: Bamberg K, Mehtälä L, Arola O, Laitinen S, Nordling P, Strandberg M, Strandberg N, Paltta J, Mali M, Espinosa-Ortega F, Pirilä L, Lundberg IE, Savukoski T, Pettersson K. Evaluation of a New Skeletal Troponin I Assay in Patients with Idiopathic Inflammatory Myopathies J Appl Lab Med. 2020 Mar 1;5(2):320-331.
4: Trentini A, Spadaro S, Rosta V, Manfrinato MC, Cervellati C, Dalla Corte F, Hanau S, Volta CA, Bellini T. Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study Biochem Med (Zagreb). 2019 Feb 15;29(1):010703.
5: Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres Nature. 2002 Aug 15;418(6899):797-801.
6: Hyytiä H, Heikkilä T, Hedberg P, Puolakanaho T, Pettersson K. Skeletal troponin I cross-reactivity in different cardiac troponin I assay versions Clin Biochem. 2015 Mar;48(4-5):313-7.
7: Sabek J, Martínez-Pérez P, García-Rupérez J. Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I Comput Biol Chem. 2019 Jun;80:147-151.
8: de Winter JM, Ottenheijm CA. A two-faced cysteine residue modulates skeletal muscle contraction. Focus on “S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca(2+) sensitivity in rat fast-twitch muscle fibers Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C314-C315.
9: Brotto MA, Biesiadecki BJ, Brotto LS, Nosek TM, Jin JP. Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility Am J Physiol Cell Physiol. 2006 Feb;290(2):C567-76.
10: Giannitsis E, Mueller C, Katus HA. Skeletal myopathies as a non-cardiac cause of elevations of cardiac troponin concentrations Diagnosis (Berl). 2019 Aug 27;6(3):189-201.

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