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Recombinant Human Sirtuin 2

$595.00

Catalog Number: B2011240 (100 ug )
Recombinant Human Sirtuin 2 is a high quality human Sirtuin 2 protein (13-319 amino acids) expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011240 Categories: ,

Description

Recombinant Human Sirtuin 2
Catalog number: B2011240
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 35.5 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Recombinant Human SIRT2 Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lee YG, Reader BF, Herman D, Streicher A, Englert JA, Ziegler M, Chung S, Karpurapu M, Park GY, Christman JW, Ballinger MN. Sirtuin 2 enhances allergic asthmatic inflammation JCI Insight. 2019 Feb 21;4(4):e124710.
2: Head PE, Zhang H, Bastien AJ, Koyen AE, Withers AE, Daddacha WB, Cheng X, Yu DS. Sirtuin 2 mutations in human cancers impair its function in genome maintenance J Biol Chem. 2017 Jun 16;292(24):9919-9931.
3: Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature. 2003 Sep 11;425(6954):191-6.
4: Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer Cancer Cell. 2013 Apr 15;23(4):464-76.
5: Ding T, Hao J. Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma Mol Med Rep. 2021 Nov;24(5):760.
6: Nguyen P, Shukla S, Liu R, Abbineni G, Smart DK. Sirt2 Regulates Radiation-Induced Injury Radiat Res. 2019 May;191(5):398-412.
7: Suzuki T, Khan MN, Sawada H, Imai E, Itoh Y, Yamatsuta K, Tokuda N, Takeuchi J, Seko T, Nakagawa H, Miyata N. Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors J Med Chem. 2012 Jun 28;55(12):5760-73.
8: Minten EV, Kapoor-Vazirani P, Li C, Zhang H, Balakrishnan K, Yu DS. SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation Cell Rep. 2021 Mar 30;34(13):108921.
9: Walker MA, Chavez J, Villet O, Tang X, Keller A, Bruce JE, Tian R. Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure JCI Insight. 2021 Feb 8;6(3):e144301.
10: Tervo AJ, Suuronen T, Kyrylenko S, Kuusisto E, Kiviranta PH, Salminen A, Leppänen J, Poso A. Discovering inhibitors of human sirtuin type 2: novel structural scaffolds J Med Chem. 2006 Nov 30;49(24):7239-41.

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