Raf-1 Protein, Active

Product Description

Raf-1 Protein, Active
Catalog number: B2019380
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5  µg
Molecular Weight or Concentration: 65 kDa
Supplied as: Resin
Applications: a molecular tool for various biochemical applications
Storage: −70°C
Keywords: 10 µg Raf-1 Protein, Active Raf-1 Protein, Raf-1 Detection Protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Morrison DK, Cutler RE. The complexity of Raf-1 regulation Curr Opin Cell Biol. 1997 Apr;9(2):174-9.
2: Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf-1 activates MAP kinase-kinase Nature. 1992 Jul 30;358(6385):417-21.
3: Blagosklonny MV, Chuman Y, Bergan RC, Fojo T. Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells Leukemia. 1999 Jul;13(7):1028-36.
4: Häfner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, Pippig S, Lohse M, Ueffing M, Kolch W. Mechanism of inhibition of Raf-1 by protein kinase A Mol Cell Biol. 1994 Oct;14(10):6696-703.
5: Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marmé D, Rapp UR. Protein kinase C alpha activates RAF-1 by direct phosphorylation Nature. 1993 Jul 15;364(6434):249-52.
6: Ziogas A, Lorenz IC, Moelling K, Radziwill G. Mitotic Raf-1 is stimulated independently of Ras and is active in the cytoplasm J Biol Chem. 1998 Sep 11;273(37):24108-14.
7: Fei X, Dou YN, Sun K, Wei J, Guo Q, Wang L, Wu X, Lv W, Jiang X, Fei Z. TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1 Exp Mol Med. 2023 Jun;55(6):1203-1217.
8: King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 Nature. 1998 Nov 12;396(6707):180-3.
9: Zang M, Hayne C, Luo Z. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1 J Biol Chem. 2002 Feb 8;277(6):4395-405.
10: Morrison DK. Mechanisms regulating Raf-1 activity in signal transduction pathways Mol Reprod Dev. 1995 Dec;42(4):507-14.

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