Protein Kinase A from Bovine Heart


Catalog Number: B2010491 (1 mg)
Protein Kinase A from bovine heart is a highly pure serine/threonine kinase. This product has been used as a tool to determine the activity of molecular probes. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Protein Kinase A from bovine heart
Catalog number: B2010491
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: na
Supplied as: Lyophilized powder
Applications: a tool to determine the activity of molecular probes
Storage: −20°C
Keywords: Protein Kinase, 3′,5′-cyclic-AMP-dependent from bovine heart, PKA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Krüger M, Linke WA. Protein kinase-A phosphorylates titin in human heart
muscle and reduces myofibrillar passive tension. J Muscle Res Cell Motil.

2: Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B,
Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles
WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a
trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide
reduces cardiac function. J Biol Chem. 2010 Sep 3;285(36):27632-40.

3: Thullner S, Gesellchen F, Wiemann S, Pyerin W, Kinzel V, Bossemeyer D. The
protein_kinase_A catalytic subunit Cbeta2: molecular characterization and
distribution of the splice variant. Biochem J. 2000 Oct 1;351(Pt 1):123-32.

4: Diering S, Stathopoulou K, Goetz M, Rathjens L, Harder S, Piasecki A, Raabe
J, Schulz S, Brandt M, Pflaumenbaum J, Fuchs U, Donzelli S, Sadayappan S,
Nikolaev VO, Flenner F, Ehler E, Cuello F. Receptor-independent modulation of
cAMP-dependent protein kinase and protein phosphatase signaling in cardiac
myocytes by oxidizing agents. J Biol Chem. 2020 Nov 6;295(45):15342-15365.

5: Rosen OM, Erlichman J. Reversible autophosphorylation of a cyclic 3′:5′-AMP-
dependent protein kinase from bovine cardiac muscle. J Biol Chem. 1975 Oct

6: Gau DM, Roy P. An in vitro Assay to Screen for Substrates of PKA Using
Phospho-motif-specific Antibodies. Bio Protoc. 2020 Apr 20;10(8):e3587.

7: Gau D, Veon W, Zeng X, Yates N, Shroff SG, Koes DR, Roy P. Threonine 89 Is an
Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A.
PLoS One. 2016 May 26;11(5):e0156313.

8: Wolf H, Hofmann F. Purification of myosin light chain kinase from bovine
cardiac muscle. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5852-5.

9: Ma Y, Pitson S, Hercus T, Murphy J, Lopez A, Woodcock J. Sphingosine
activates protein kinase A type II by a novel cAMP-independent mechanism. J Biol
Chem. 2005 Jul 15;280(28):26011-7.
10: Rider MH, Vandamme J, Lebeau E, Vertommen D, Vidal H, Rousseau GG,
Vandekerckhove J, Hue L. The two forms of bovine heart
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative
splicing. Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):405-11.

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