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PPAR α human (Expressed in E. coli)

$595.00

Catalog Number: B2010432 (10 ug)
PPAR, α human (Expressed in E. coli) is a high quality research product used as Peroxisome proliferator-activated receptor expressed and purified from E. coli. Custom bulk orders of this product are available upon request.
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SKU: B2010432 Categories: , Tag:

Description

PPAR, α human (Expressed in E. coli)
Catalog number: B2010432
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 54 kDa
Supplied as: Solution
Appearance: Solution
Applications: Peroxisome proliferator-activated receptor expressed and purified from E. coli.
Storage: −20°C
Keywords: NR1C1, MGC2452, PPAR, MGC2237, PPARalpha, hPPAR, eroxisome proliferator-activated receptor
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Bougarne N, Weyers B, Desmet SJ, Deckers J, Ray DW, Staels B, De Bosscher K.
Molecular Actions of PPARα in Lipid Metabolism and Inflammation. Endocr Rev.
2018 Oct 1;39(5):760-802.

2: Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARα action and its
impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty
liver disease. J Hepatol. 2015 Mar;62(3):720-33.

3: Takada I, Makishima M. Peroxisome proliferator-activated receptor agonists
and antagonists: a patent review (2014-present). Expert Opin Ther Pat. 2020
Jan;30(1):1-13.

4: Han L, Shen WJ, Bittner S, Kraemer FB, Azhar S. PPARs: regulators of
metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α.
Future Cardiol. 2017 May;13(3):259-278.

5: Kersten S, Stienstra R. The role and regulation of the peroxisome
proliferator activated receptor alpha in human liver. Biochimie. 2017
May;136:75-84.

6: Wójtowicz S, Strosznajder AK, Jeżyna M, Strosznajder JB. The Novel Role of
PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and
Other Neurodegenerative Disorders. Neurochem Res. 2020 May;45(5):972-988.

7: Preidis GA, Kim KH, Moore DD. Nutrient-sensing nuclear receptors PPARα and
FXR control liver energy balance. J Clin Invest. 2017 Apr 3;127(4):1193-1201.

8: Sasaki Y, Raza-Iqbal S, Tanaka T, Murakami K, Anai M, Osawa T, Matsumura Y,
Sakai J, Kodama T. Gene Expression Profiles Induced by a Novel Selective
Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate.
Int J Mol Sci. 2019 Nov 13;20(22):5682.
9: Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M,
Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Hepatoprotective
effects of the dual peroxisome proliferator-activated receptor alpha/delta
agonist, GFT505, in rodent models of nonalcoholic fatty liver
disease/nonalcoholic steatohepatitis. Hepatology. 2013 Dec;58(6):1941-52.

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