Pigment Epithelium-derived Factor (Human)

Description

Pigment Epithelium-derived Factor (Human, Recombinant)
Catalog number: B2010322
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Pigment Epithelium-derived Factor (Human, Recombinant) expressed in E. coli. This protein acts as a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family.
Storage: -20C
Keywords: rHuPEDF; SerpinF1; EPC-1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Huang KT, Lin CC, Tsai MC, Chen KD, Chiu KW. Pigment epithelium-derived
factor in lipid metabolic disorders. Biomed J. 2018 Apr;41(2):102-108.

2: Brook N, Brook E, Dharmarajan A, Chan A, Dass CR. Pigment epithelium-derived
factor regulation of neuronal and stem cell fate. Exp Cell Res. 2020 Apr
15;389(2):111891.

3: Xi L. Pigment Epithelium-Derived Factor as a Possible Treatment Agent for
Choroidal Neovascularization. Oxid Med Cell Longev. 2020 Mar 6;2020:8941057.

4: Miller I, Bar-Joseph H, Nemerovsky L, Ben-Ami I, Shalgi R. Pigment
epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features. J
Endocrinol. 2020 May;245(2):291-300.

5: Brook N, Brook E, Dharmarajan A, Chan A, Dass CR. The role of pigment
epithelium-derived factor in protecting against cellular stress. Free Radic Res.
2019 Dec;53(11-12):1166-1180.

6: Yamagishi SI, Koga Y, Sotokawauchi A, Hashizume N, Fukahori S, Matsui T, Yagi
M. Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer. Curr
Pharm Des. 2019;25(3):313-324.

7: Yamagishi SI, Matsui T. Pigment Epithelium_Derived Factor: A Novel
Therapeutic Target for Cardiometabolic Diseases and Related Complications. Curr
Med Chem. 2018;25(13):1480-1500.

8: Baxter-Holland M, Dass CR. Pigment epithelium_derived factor: a key mediator
in bone homeostasis and potential for bone regenerative therapy. J Pharm
Pharmacol. 2018 Sep;70(9):1127-1138.

9: Huang WT, Chong IW, Chen HL, Li CY, Hsieh CC, Kuo HF, Chang CY, Chen YH, Liu
YP, Lu CY, Liu YR, Liu PL. Pigment epithelium_derived factor inhibits lung
cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer
Lett. 2019 Feb 1;442:287-298.

10: Ma S, Wang S, Li M, Zhang Y, Zhu P. The effects of pigment epithelium-
derived factor on atherosclerosis: putative mechanisms of the process. Lipids
Health Dis. 2018 Oct 17;17(1):240.
11: Akpinar MY, Kahramanoglu Aksoy E, Pirincci Sapmaz F, Ceylan Dogan O, Uzman
M, Nazligul Y. Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac
Disease. Med Princ Pract. 2019;28(3):236-241.

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