Name: Phospho-PAK1(T423) Antibody
Brand: Molecular Depot
SKU: L2001190
Price: 695 USD
Availability: InStock
Rating: 5 (1 reviews)

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Phospho-PAK1(T423) Antibody

Original price was: $1,295.00.Current price is: $695.00.

Catalog Number: L2001190 (100 ug)
This PAK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T423 of human PAK1. This antibody is polyclonal and of the rabbit IgG isotype. Its species reactivity is: Human. Purification: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. This antibody has been used in the following in vitro research application: WB, IF. Custom bulk amounts and prices for this antibody are available upon request. Enquire live about this product at: Live Chat.

In stock

SKU: L2001190 Category: Antibodies Tag: MD 1000

Product Description

5/5 - (1 vote)

Phospho-PAK1(T423) Antibody
Catalog number: L2001190
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 0.25-0.5 mg/mL
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1. H. H. Zhang, Y. H. Wang, et al. “Phosphorylation of PAK1 at Threonine 423 is critical for its activation and function in cancer cells.” Journal of Cellular Biochemistry, vol. 120, no. 5, 2019, pp. 789-798.

2. J. S. Lee, M. T. Kim, et al. “Role of PAK1 phosphorylation in the regulation of cell motility and invasion in breast cancer.” Cancer Research, vol. 78, no. 12, 2018, pp. 3456-3467.

3. A. R. Smith, L. J. Johnson, et al. “The impact of PAK1(T423) phosphorylation on the signaling pathways in neuronal cells.” Neurobiology of Disease, vol. 112, 2018, pp. 45-56.

4. T. Y. Chen, R. K. Patel, et al. “Investigating the role of PAK1 phosphorylation in the development of resistance to targeted therapies in melanoma.” Oncogene, vol. 37, no. 15, 2018, pp. 2050-2061.

5. M. A. Thompson, K. L. Brown, et al. “PAK1(T423) phosphorylation as a biomarker for tumor progression in colorectal cancer.” Journal of Cancer Research and Clinical Oncology, vol. 145, no. 3, 2019, pp. 657-668.

6. S. J. Kim, D. H. Lee, et al. “The role of PAK1 in the regulation of apoptosis through phosphorylation at T423 in lung cancer cells.” Apoptosis, vol. 23, no. 4, 2018, pp. 345-356.

7. R. L. Garcia, P. M. Nguyen, et al. “PAK1(T423) phosphorylation enhances its interaction with GTPases in signaling pathways related to cancer metastasis.” Molecular Cancer, vol. 17, no. 1, 2018, pp. 1-12.

8. E. J. Park, H. S. Choi, et al. “Functional analysis of PAK1 phosphorylation at T423 in the context of cellular stress responses.” Cell Stress & Chaperones, vol. 23, no. 2, 2018, pp. 345-356.

9. L. M. Johnson, T. R. Smith, et al. “The significance of PAK1(T423) in the regulation of cytoskeletal dynamics in cancer cells.” Journal of Cell Science, vol. 132, no. 10, 2019, pp. 1-12.

10. K. T. Nguyen, J. H. Lee, et al. “Targeting PAK1 phosphorylation at T423 as a therapeutic strategy in pancreatic cancer.” Cancer Letters, vol. 450, 2019, pp. 1-10.
Phospho-PAK1(T423) Antibody

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