Nicastrin Antibody (High Specificity)

Description

Nicastrin Antibody (High Specificity)
Catalog number: B2010561
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 uL
Molecular Weight or Concentration: 150 kDa
Supplied as: Ascites fluid
Applications: molecular tool in the study of Nicastrin
Storage: -20C
Keywords: Anti-Nicastrin Antibody
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hsu CH, Liou GG, Jiang YJ. Nicastrin Deficiency Induces Tyrosinase-Dependent
Depigmentation and Skin Inflammation. J Invest Dermatol. 2020
Feb;140(2):404-414.e13.

2: De Strooper B. Nicastrin: gatekeeper of the gamma-secretase complex. Cell.
2005 Aug 12;122(3):318-20.

3: Xiao XM, Yang WZ, Lin LH, Li CR. Two novel nicastrin mutations in Chinese
families with acne inversa. J Dermatol. 2020 Dec;47(12):e449-e451.

4: Garcovich S, Tricarico PM, Nait-Meddour C, Giovanardi G, Peris K, Crovella S,
Boniotto M. Novel nicastrin mutation in hidradenitis suppurativa-Dowling-Degos
disease clinical phenotype: more than just clinical overlap? Br J Dermatol. 2020
Oct;183(4):758-759.

5: Nishimura M. [Nicastrin]. Nihon Rinsho. 2011 Oct;69 Suppl 8:115-8. Japanese.

6: Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan
X, Li X, Tang M, Gallagher T, Yu G, Beutler B. Essential requirement for
nicastrin in marginal zone and B-1 B cell development. Proc Natl Acad Sci U S A.
2020 Mar 3;117(9):4894-4901.

7: Arai MA, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T,
Ishibashi M. The Notch inhibitor cowanin accelerates nicastrin degradation. Sci
Rep. 2018 Mar 29;8(1):5376.

8: Hsu CH, Jiang YJ. Does Nicastrin Inadequacy Cause Melanocytotoxicity in Human
Skin as in the Fish Counterpart? J Invest Dermatol. 2021 May;141(5):1334-1338.

9: He Y, Xu H, Li C, Zhang X, Zhou P, Xiao X, Zhang W, Wu Y, Zeng R, Wang B.
Nicastrin/miR-30a-3p/RAB31 Axis Regulates Keratinocyte Differentiation by
Impairing EGFR Signaling in Familial Acne Inversa. J Invest Dermatol. 2019
Jan;139(1):124-134.
10: Urban S. Nicastrin guards Alzheimer’s gate. Proc Natl Acad Sci U S A. 2016
Feb 2;113(5):1112-4.

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