Myeloperoxidase from Human Neutrophils

Product Description

Myeloperoxidase from Human Neutrophils
Catalog number: B2012185
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 ug
Molecular Weight or Concentration: > 1,000 U/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: MPO, pANCA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Aratani Y. Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function Arch Biochem Biophys. 2018 Feb 15;640:47-52.
2: Ndrepepa G. Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease Clin Chim Acta. 2019 Jun;493:36-51.
3: Metzler KD, Fuchs TA, Nauseef WM, Reumaux D, Roesler J, Schulze I, Wahn V, Papayannopoulos V, Zychlinsky A. Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity Blood. 2011 Jan 20;117(3):953-9.
4: Guilpain P, Servettaz A, Batteux F, Guillevin L, Mouthon L. Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies Autoimmun Rev. 2008 Jun;7(6):421-5.
5: Manchanda K, Kolarova H, Kerkenpaß C, Mollenhauer M, Vitecek J, Rudolph V, Kubala L, Baldus S, Adam M, Klinke A. MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1859-1867.
6: Galijasevic S. The development of myeloperoxidase_ inhibitors Bioorg Med Chem Lett. 2019 Jan 1;29(1):1-7.
7: Hu CH, Neissel Valente MW, Halpern OS, Jusuf S, Khan JA, Locke GA, Duke GJ, Liu X, Duclos FJ, Wexler RR, Kick EK, Smallheer JM. Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase_ (MPO) Bioorg Med Chem Lett. 2021 Jun 15;42:128010.
8: Soubhye J, Furtmüller PG, Dufrasne F, Obinger C. Inhibition of Myeloperoxidase_ Handb Exp Pharmacol. 2021;264:261-285.
9: Nauseef WM. Biosynthesis of human myeloperoxidase Arch Biochem Biophys. 2018 Mar 15;642:1-9.
10: Vanhamme L, Zouaoui Boudjeltia K, Van Antwerpen P, Delporte C. The other myeloperoxidase: Emerging functions Arch Biochem Biophys. 2018 Jul 1;649:1-14.

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