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Mononucleosomes (H2A.X)

Original price was: $1,995.00.Current price is: $995.00.

Catalog Number: B2016657 (10 µg)
Mononucleosomes (H2A.X) is a high quality structural units of chromatin that play a crucial role in regulating gene expression and DNA repair processes within cells. They are involved in maintaining the integrity of the genome and ensuring proper functioning of various cellular activities. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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Product Description

Mononucleosomes (H2A.X)
Catalog number: B2016657
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: ~111.7 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Recombinant Mononucleosomes (H2A.X)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R, Picketts DJ, Yang X. A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein J Biol Chem. 2004 May 7;279(19):20369-77.
2: van Vugt JJ, de Jager M, Murawska M, Brehm A, van Noort J, Logie C. Multiple aspects of ATP-dependent nucleosome translocation by RSC and Mi-2 are directed by the underlying DNA sequence PLoS One. 2009 Jul 23;4(7):e6345.
3: Eisfeld K, Candau R, Truss M, Beato M. Binding of NF1 to the MMTV promoter in nucleosomes: influence of rotational phasing, translational positioning and histone H1 Nucleic Acids Res. 1997 Sep 15;25(18):3733-42.
4: Tomschik M, Karymov MA, Zlatanova J, Leuba SH. The archaeal histone-fold protein HMf organizes DNA into bona fide chromatin fibers Structure. 2001 Dec;9(12):1201-11.
5: Cavalar M, Möller C, Offermann S, Krohn NM, Grasser KD, Peterhänsel C. The interaction of DOF transcription factors with nucleosomes depends on the positioning of the binding site and is facilitated by maize HMGB5 Biochemistry. 2003 Feb 25;42(7):2149-57.
6: Kanai Y, Kyuwa S, Miura K, Kurosawa Y. Induction and natural occurrence of serum nucleosomal DNA in autoimmune MRL/lpr/lpr mice: its relation to apoptosis in the thymus Immunol Lett. 1995 May;46(1-2):207-14.
7: Imbalzano AN. SWI/SNF complexes and facilitation of TATA binding protein:nucleosome interactions Methods. 1998 Aug;15(4):303-14.
8: Kwon Y, Seong C, Chi P, Greene EC, Klein H, Sung P. ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54 J Biol Chem. 2008 Apr 18;283(16):10445-52.
9: Deng Z, Chen CJ, Chamberlin M, Lu F, Blobel GA, Speicher D, Cirillo LA, Zaret KS, Lieberman PM. The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation Mol Cell Biol. 2003 Apr;23(8):2633-44.
10: Krajewski WA. Isw1a does not have strict limitations on the length of extranucleosomal DNAs for mobilization of nucleosomes assembled with HeLa cell histones J Biomol Struct Dyn. 2014 Apr;32(4):523-31.

Products Related to Mononucleosomes (H2A.X) can be found at Proteins

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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