Interleukin-17 (IL-17) (Human Recombinant)

Description

Human Interleukin-17 (IL-17)
Catalog number: B2010267
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: highly pure recombinant human Interleukin 17A (expressed in E. coli). IL-17A is involved in innate and acquired immunity through the accumulation of polymorphonuclear neutrophil leukocytes.
Storage: -20C
Keywords: rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um.

References:
“”1: Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein
WM, Judo M, Ayanoglu G, McClanahan TK, Li X, Cua DJ. Interleukin-23-Independent
IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015
Oct 20;43(4):727-38.

2: Frangou E, Chrysanthopoulou A, Mitsios A, Kambas K, Arelaki S, Angelidou I,
Arampatzioglou A, Gakiopoulou H, Bertsias GK, Verginis P, Ritis K, Boumpas DT.
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human
systemic lupus erythematosus (SLE) through NETs decorated with tissue factor
(TF) and interleukin-17A (IL-17A). Ann Rheum Dis. 2019 Feb;78(2):238-248.
PMC6352428.

3: Glatt S, Baeten D, Baker T, Griffiths M, Ionescu L, Lawson ADG, Maroof A,
Oliver R, Popa S, Strimenopoulou F, Vajjah P, Watling MIL, Yeremenko N, Miossec
P, Shaw S. Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic
arthritis: evidence from preclinical experiments and a randomised placebo-
controlled clinical trial that IL-17F contributes to human chronic tissue
inflammation. Ann Rheum Dis. 2018 Apr;77(4):523-532.

4: Brembilla NC, Senra L, Boehncke WH. The IL-17 Family of Cytokines in
Psoriasis: IL-17A and Beyond. Front Immunol. 2018 Aug 2;9:1682.

5: Kolbinger F, Huppertz C, Mir A, Padova FD. IL-17A and Multiple Sclerosis:
Signaling Pathways, Producing Cells and Target Cells in the Central Nervous
System. Curr Drug Targets. 2016;17(16):1882-1893.

6: Blauvelt A, Chiricozzi A. The Immunologic Role of IL-17 in Psoriasis and
Psoriatic Arthritis Pathogenesis. Clin Rev Allergy Immunol. 2018
Dec;55(3):379-390.

7: Ruiz de Morales JMG, Puig L, Daudén E, Cañete JD, Pablos JL, Martín AO,
Juanatey CG, Adán A, Montalbán X, Borruel N, Ortí G, Holgado-Martín E, García-
Vidal C, Vizcaya-Morales C, Martín-Vázquez V, González-Gay MÁ. Critical role of
interleukin (IL)-17 in inflammatory and immune disorders: An updated review of
the evidence focusing in controversies. Autoimmun Rev. 2020 Jan;19(1):102429.

8: Goepfert A, Lehmann S, Wirth E, Rondeau JM. The human IL-17A/F heterodimer: a
two-faced cytokine with unique receptor recognition properties. Sci Rep. 2017
Aug 21;7(1):8906.

9: Kan J, Mishima S, Kashiwakura J, Sasaki-Sakamoto T, Seki M, Saito S, Ra C,
Tokuhashi Y, Okayama Y. Interleukin-17A expression in human synovial mast cells
in rheumatoid arthritis and osteoarthritis. Allergol Int. 2016 Sep;65
Suppl:S11-6.

10: McGonagle DG, McInnes IB, Kirkham BW, Sherlock J, Moots R. The role of
IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and
controversies. Ann Rheum Dis. 2019 Sep;78(9):1167-1178.

11: Krstic J, Obradovic H, Kukolj T, Mojsilovic S, Okic-Dordevic I, Bugarski D,
Santibanez JF. An Overview of Interleukin-17A and Interleukin-17 Receptor A
Structure, Interaction and Signaling. Protein Pept Lett. 2015;22(7):570-8.

12: Yu C, Niu X, Du Y, Chen Y, Liu X, Xu L, Iwakura Y, Ma X, Li Y, Yao Z, Deng
W. IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4
axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment. Cancer
Immunol Immunother. 2020 Jan;69(1):115-126.

13: Kaur R, Rawat AK, Kumar S, Aadil W, Akhtar T, Narang T, Chopra D.
Association of genetic polymorphism of interleukin-17A & interleukin-17F with
susceptibility of psoriasis. Indian J Med Res. 2018 Oct;148(4):422-426. “”

Products Related to Human Interleukin-17 (IL-17): COVID-19