Insulin-like Growth factor-2 (Human)

Description

Insulin-like Growth factor-2 (Human)
Catalog number: B2010279
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Insulin-like Growth factor-2 (Human) expressed in E. coli . This protein acts as a mitogenic cytokine that binds to IGF type 1 receptor and is involved in modulating the growth in many tissues.
Storage: -20C
Keywords: rHuIGF-2; Somatamedin A; IGF-II
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Holly JMP, Biernacka K, Perks CM. The Neglected Insulin: IGF-II, a Metabolic
Regulator with Implications for Diabetes, Obesity, and Cancer. Cells. 2019 Oct
6;8(10):1207.

2: Bach LA. Current ideas on the biology of IGFBP-6: More than an IGF-II
inhibitor? Growth Horm IGF Res. 2016 Oct-Dec;30-31:81-86.

3: Steinmetz AB, Stern SA, Kohtz AS, Descalzi G, Alberini CM. Insulin-Like
Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in
Mice. J Neurosci. 2018 Jan 24;38(4):1015-1029.

4: Cottam Jones JM, Harris PW, Scanlon DB, Forbes BE, Brimble MA, Abell AD.
Fluorescent IGF-II analogues for FRET-based investigations into the binding of
IGF-II to the IGF-1R. Org Biomol Chem. 2016 Mar 7;14(9):2698-705.

5: Lauterio TJ. The effects of IGF-I and IGF-II on cell growth and
differentiation in the central nervous system. Adv Exp Med Biol. 1992;321:31-6.

6: Kiess W, Yang Y, Kessler U, Hoeflich A. Insulin-like growth factor II (IGF-
II) and the IGF-II/mannose-6-phosphate receptor: the myth continues. Horm Res.
1994;41 Suppl 2:66-73.

7: Brown J, Jones EY, Forbes BE. Keeping IGF-II under control: lessons from the
IGF-II-IGF2R crystal structure. Trends Biochem Sci. 2009 Dec;34(12):612-9.

8: Charnock JC, Dilworth MR, Aplin JD, Sibley CP, Westwood M, Crocker IP. The
impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model
of fetal growth restriction. Am J Physiol Endocrinol Metab. 2016 Jan
1;310(1):E24-31.

9: Giudice LC, Lamson G, Rosenfeld RG, Irwin JC. Insulin-like growth factor-II
(IGF-II) and IGF binding proteins in human endometrium. Ann N Y Acad Sci.
1991;626:295-307.

10: Bradley JP, Han VK, Roth DA, Levine JP, McCarthy JG, Longaker MT. Increased
IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest
evidence for a paracrine role of insulin-like growth factors in suture fusion.
Plast Reconstr Surg. 1999 Jul;104(1):129-38.

11: O’Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem
Cell Biol. 1998 Jul;30(7):767-71.

12: Weber MM, Melmed S, Rosenbloom J, Yamasaki H, Prager D. Rat somatotroph
insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.
Endocrinology. 1992 Nov;131(5):2147-53.
13: Brown J, Jones EY, Forbes BE. Interactions of IGF-II with the IGF2R/cation-
independent mannose-6-phosphate receptor mechanism and biological outcomes.
Vitam Horm. 2009;80:699-719.

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