IKKβ Human Recombinant

Product Description

IKKβ Human Recombinant
Catalog number: B2016924
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 105 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: IĸB kinase β, IKK2, IKBKB, NFKBIKB, Inhibitor of Nuclear Factor ĸ-B Kinase Subunit β, Nuclear Factor NF-ĸ-B-inhibitor Kinase β
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Prescott JA, Balmanno K, Mitchell JP, Okkenhaug H, Cook SJ. IKKα plays a major role in canonical NF-κB signalling in colorectal cells Biochem J. 2022 Feb 11;479(3):305-325.
3: Orlikova B, Schumacher M, Juncker T, Yan CC, Inayat-Hussain SH, Hajjouli S, Cerella C, Dicato M, Diederich M. Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation Food Chem Toxicol. 2013 Sep;59:572-8.
4: Zhang D, Wang X, Chen S, Chen S, Yu W, Liu X, Yang G, Tao Y, Tang X, Bu D, Zhang H, Kong W, Tang C, Huang Y, Du J, Jin H. Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation Clin Sci (Lond). 2019 Oct 30;133(20):2045-2059.
5: Rabadi MM, Han SJ, Kim M, D’Agati V, Lee HT. Peptidyl arginine deiminase-4 exacerbates ischemic AKI by finding NEMO Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1180-F1190.
6: Nizami S, Millar V, Arunasalam K, Zarganes-Tzitzikas T, Brough D, Tresadern G, Brennan PE, Davis JB, Ebner D, Di Daniel E. A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation Sci Rep. 2021 Jul 28;11(1):15319.
7: Huang Y, Lin S, Zhan F, Xiao L, Zhan Y, Wang R. OX40-Fc Fusion Protein Alleviates PD-1-Fc-Aggravated Rheumatoid Arthritis by Inhibiting Inflammatory Response Comput Math Methods Med. 2022 Feb 17;2022:6244175.
8: Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution Biochim Biophys Acta Proteins Proteom. 2020 Dec;1868(12):140526.
9: Ren J, Chen X, Chen ZJ. IKKβ is an IRF5 kinase that instigates inflammation Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17438-43.
10: de Jong SJ, Albrecht JC, Schmidt M, Müller-Fleckenstein I, Biesinger B. Activation of noncanonical NF-kappaB signaling by the oncoprotein Tio J Biol Chem. 2010 May 28;285(22):16495-503.

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