Human Thrombospondin-1

Description

Human Thrombospondin-1
Catalog number: B2014333
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 μg
Molecular Weight or Concentration: 127.5 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: THBS, THBS1, TSP, TSP1, Thrombospondin-1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kaur S, Bronson SM, Pal-Nath D, Miller TW, Soto-Pantoja DR, Roberts DD. Functions of Thrombospondin-1 in the Tumor Microenvironment Int J Mol Sci. 2021 Apr 27;22(9):4570.
2: Binsker U, Kohler TP, Hammerschmidt S. Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria J Innate Immun. 2019;11(4):303-315.
3: Murphy-Ullrich JE, Suto MJ. Thrombospondin-1 regulation of latent TGF-_ activation: A therapeutic target for fibrotic disease Matrix Biol. 2018 Aug;68-69:28-43.
4: Roberts DD, Isenberg JS. CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C201-C213.
5: Kale A, Rogers NM, Ghimire K. Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine Int J Mol Sci. 2021 Apr 14;22(8):4062.
6: Aburima A, Berger M, Spurgeon BEJ, Webb BA, Wraith KS, Febbraio M, Poole AW, Naseem KM. Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets Blood. 2021 Feb 4;137(5):678-689.
7: Yamashiro Y, Thang BQ, Ramirez K, Shin SJ, Kohata T, Ohata S, Nguyen TAV, Ohtsuki S, Nagayama K, Yanagisawa H. Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling Proc Natl Acad Sci U S A. 2020 May 5;117(18):9896-9905.
8: Sipes JM, Murphy-Ullrich JE, Roberts DD. Thrombospondins: Purification of human platelet thrombospondin-1 Methods Cell Biol. 2018;143:347-369.
9: Sun J, Ge X, Wang Y, Niu L, Tang L, Pan S. USF2 knockdown downregulates THBS1 to inhibit the TGF-_ signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury Pharmacol Res. 2022 Feb;176:105962.
10: Bissinger R, Petkova-Kirova P, Mykhailova O, Oldenborg PA, Novikova E, Donkor DA, Dietz T, Bhuyan AAM, Sheffield WP, Grau M, Artunc F, Kaestner L, Acker JP, Qadri SM. Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells Cell Commun Signal. 2020 Sep 18;18(1):155.

Products Related to Human Thrombospondin-1 can be found at Proteins