Human Sonic Hedgehog (SHH) Protein

Product Description

Human Sonic Hedgehog (SHH) Protein
Catalog number: B2016130
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 μg
Molecular Weight or Concentration: 19-22 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: HHG 1, HHG1, HLP3, HPE3, MCOPCB5, SHH, SMMCI, Sonic hedgehog protein, TPT, TPTPS
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Fares J, Bou Diab Z, Nabha S, Fares Y. Neurogenesis in the adult hippocampus: history, regulation, and prospective roles Int J Neurosci. 2019 Jun;129(6):598-611.
2: Xia YP, He QW, Li YN, Chen SC, Huang M, Wang Y, Gao Y, Huang Y, Wang MD, Mao L, Hu B. Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage PLoS One. 2013 Jul 23;8(7):e68891.
3: Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators; Bioulac-Sage P, Letouzé E, Zucman-Rossi J. Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation Gastroenterology. 2017 Mar;152(4):880-894.e6.
4: Wang XZ, Zhang HH, Qian YL, Tang LF. Sonic hedgehog (Shh) and CC chemokine ligand 2 signaling pathways in asthma J Chin Med Assoc. 2019 May;82(5):343-350.
5: Wang X, Tan S, Yang S, Liu X, Lei J, Li H. Activation of Sonic Hedgehog Signaling Pathway Regulates Human Trabecular Meshwork Cell Function J Ocul Pharmacol Ther. 2023 Sep;39(7):430-438.
6: Liu Y, Luan Y, Ma K, Zhang Z, Liu Y, Chen X. ISL1 Promotes Human Glioblastoma-Derived Stem Cells’ Self-Renewal by Activation of Sonic Hedgehog/GLI1 Function Stem Cells Dev. 2022 May;31(9-10):258-268.
7: Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC. A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions Am J Surg Pathol. 2018 Apr;42(4):553-560.
8: Hu X, Xiao Y, Sun J, Ji B, Luo S, Wu B, Zheng C, Wang P, Xu F, Cheng K, Hua H, Li D. New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors Acta Pharm Sin B. 2021 May;11(5):1148-1157.
9: Ye X, Hong W, Hao B, Peng G, Huang L, Zhao Z, Zhou Y, Zheng M, Li C, Liang C, Yi E, Pu J, Li B, Ran P. PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway Respir Res. 2018 Mar 2;19(1):37.
10: Warzecha J, Göttig S, Brüning C, Lindhorst E, Arabmothlagh M, Kurth A. Sonic hedgehog protein promotes proliferation and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro J Orthop Sci. 2006 Oct;11(5):491-6.

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