Human Recombinant Cardiotrophin 1 Protein

Description

Human Recombinant Cardiotrophin 1 Protein
Catalog number: B2012874
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 ug
Molecular Weight or Concentration: 21.2 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Cardiotrophin 1 Protein, Human, Recombinant
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Pennica D, Swanson TA, Shaw KJ, Kuang WJ, Gray CL, Beatty BG, Wood WI. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization Cytokine. 1996 Mar;8(3):183-9.
2: Fritzenwanger M, Meusel K, Foerster M, Kuethe F, Krack A, Figulla HR. Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes Cytokine. 2007 Jun;38(3):137-44.
3: Lang C, Shu X, Peng L, Yu X. The ERK signaling pathway is involved in cardiotrophin-1-induced neural differentiation of human umbilical cord blood mesenchymal stem cells in vitro Cytotechnology. 2019 Oct;71(5):977-988.
4: Ancín M, Sanz-Barrio R, Santamaría E, Millán AF, Larraya L, Veramendi J, Farran I. Functional Improvement of Human Cardiotrophin 1 Produced in Tobacco Chloroplasts by Co-expression with Plastid Thioredoxin m Plants (Basel). 2020 Feb 2;9(2):183.
5: Farran I, Río-Manterola F, Iñiguez M, Gárate S, Prieto J, Mingo-Castel AM. High-density seedling expression system for the production of bioactive human cardiotrophin-1, a potential therapeutic cytokine, in transgenic tobacco chloroplasts Plant Biotechnol J. 2008 Jun;6(5):516-27.
6: Carneros D, Santamaría EM, Larequi E, Vélez-Ortiz JM, Reboredo M, Mancheño U, Perugorria MJ, Navas P, Romero-Gómez M, Prieto J, Hervás-Stubbs S, Bustos M. Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2 macrophage polarization FASEB J. 2019 Jun;33(6):7578-7587.
7: Ng LL, O’Brien RJ, Demme B, Jennings S. Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure Clin Sci (Lond). 2002 Apr;102(4):411-6.
8: Castaño D, Larequi E, Belza I, Astudillo AM, Martínez-Ansó E, Balsinde J, Argemi J, Aragon T, Moreno-Aliaga MJ, Muntane J, Prieto J, Bustos M. Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation J Hepatol. 2014 May;60(5):1017-25.
9: Escoté X. Potential clinical treatment of colitis with cardiotrophin-1 Clin Sci (Lond). 2018 Oct 18;132(20):2169-2174.
10: Robador PA, San José G, Rodríguez C, Guadall A, Moreno MU, Beaumont J, Fortuño A, Díez J, Martínez-González J, Zalba G. HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia Cardiovasc Res. 2011 Nov 1;92(2):247-55.

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