Human Lymphotactin/XCL1 (Recombinant)

Description

Human Lymphotactin/XCL1
Catalog number: B2010368
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Lymphotactin/XCL1 expressed in E. coli. This protein acts as a C class chemokine produced by T, NK, and NKT cells during infectious and inflammatory responses.
Storage: -20C
Keywords: rHuLymphotactin/XCL1; ATAC; SCYC1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Fox JC, Tyler RC, Guzzo C, Tuinstra RL, Peterson FC, Lusso P, Volkman BF.
Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-
Inhibitory Dimer Conformation. ACS Chem Biol. 2015 Nov 20;10(11):2580-8.

2: Zavala-Flores LM, Villatoro-Hernandez J, Gamez-Escobedo A, Franco-Molina M,
Rangel-Colmenero BR, Villanueva-Olivo A, Gutierrez-Puente Y, de Oca-Luna RM,
Valdés-Flores J, Saucedo-Cardenas O. Production of biologically active human
lymphotactin (XCL1) by Lactococcus lactis. Biotechnol Lett. 2009
Feb;31(2):215-20.

3: Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S,
Kempermann G, Walker TL. The systemic exercise-released chemokine
lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell
proliferation and neuronal differentiation. Sci Rep. 2019 Aug 14;9(1):11831.

4: Zhang SM, Tian FJ, Zeng WH, Ma XL, Ren JB, Lin Y. XCL1-XCR1 pathway promotes
trophoblast invasion at maternal-fetal interface by inducing MMP-2/MMP-9
activity. Am J Reprod Immunol. 2018 Sep;80(3):e12990.

5: Tuinstra RL, Peterson FC, Elgin ES, Pelzek AJ, Volkman BF. An engineered
second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like
conformation with XCR1 agonist activity. Biochemistry. 2007 Mar
13;46(10):2564-73.

6: Volkman BF, Liu TY, Peterson FC. Chapter 3. Lymphotactin structural dynamics.
Methods Enzymol. 2009;461:51-70.

7: Endres M, Andreas K, Kalwitz G, Freymann U, Neumann K, Ringe J, Sittinger M,
Häupl T, Kaps C. Chemokine profile of synovial fluid from normal, osteoarthritis
and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human
subchondral mesenchymal progenitor cells. Osteoarthritis Cartilage. 2010
Nov;18(11):1458-66.

8: Laudanski P, Lemancewicz A, Kuc P, Charkiewicz K, Ramotowska B, Kretowska M,
Jasinska E, Raba G, Karwasik-Kajszczarek K, Kraczkowski J, Laudanski T.
Chemokines profiling of patients with preterm birth. Mediators Inflamm.
2014;2014:185758.
9: Egesten A, Olin AI, Linge HM, Yadav M, Mörgelin M, Karlsson A, Collin M. SpeB
of Streptococcus pyogenes differentially modulates antibacterial and receptor
activating properties of human chemokines. PLoS One. 2009;4(3):e4769.

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