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Human Exodus-2/CCL21 (Recombinant)

$695.00 $495.00

Catalog Number: B2010357 (10 ug)
Human Exodus-2/CCL21 is a high quality research product used as highly pure Human Exodus-2/CCL21 expressed in E. coli. This protein acts as a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cell and dendritic cells into lymphoid T areas. Custom bulk orders of this product are available upon request.

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SKU: B2010357 Categories: , ,

Description

Human Exodus-2/CCL21
Catalog number: B2010357
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Exodus-2/CCL21 expressed in E. coli. This protein acts as a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cell and dendritic cells into lymphoid T areas.
Storage: -20C
Keywords: rHuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Christopherson K 2nd, Brahmi Z, Hromas R. Regulation of naïve fetal T-cell
migration by the chemokines Exodus-2 and Exodus-3. Immunol Lett. 1999 Aug
3;69(2):269-73.

2: Robertson MJ, Williams BT, Christopherson K 2nd, Brahmi Z, Hromas R.
Regulation of human natural killer cell migration and proliferation by the
exodus subfamily of CC chemokines. Cell Immunol. 2000 Jan 10;199(1):8-14.

3: Nguyen T, Lagman C, Chung LK, Chen CH, Poon J, Ong V, Voth BL, Yang I.
Insights into CCL21’s roles in immunosurveillance and immunotherapy for gliomas.
J Neuroimmunol. 2017 Apr 15;305:29-34.

4: Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C,
Broxmeyer HE. Isolation and characterization of Exodus-2, a novel C-C chemokine
with a unique 37-amino acid carboxyl-terminal extension. J Immunol. 1997 Sep
15;159(6):2554-8.

5: Christopherson KW 2nd, Hood AF, Travers JB, Ramsey H, Hromas RA. Endothelial
induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. Blood.
2003 Feb 1;101(3):801-6.

6: Dijkstra IM, Hulshof S, van der Valk P, Boddeke HW, Biber K. Cutting edge:
activity of human adult microglia in response to CC chemokine ligand 21. J
Immunol. 2004 Mar 1;172(5):2744-7.

7: Christopherson KW 2nd, Campbell JJ, Hromas RA. Transgenic overexpression of
the CC chemokine CCL21 disrupts T-cell migration. Blood. 2001 Dec
15;98(13):3562-8.

8: Christopherson KW 2nd, Campbell JJ, Travers JB, Hromas RA. Low-molecular-
weight heparins inhibit CCL21-induced T cell adhesion and migration. J Pharmacol
Exp Ther. 2002 Jul;302(1):290-5.
9: Jenh CH, Cox MA, Kaminski H, Zhang M, Byrnes H, Fine J, Lundell D, Chou CC,
Narula SK, Zavodny PJ. Cutting edge: species specificity of the CC chemokine
6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a
ligand for the human or mouse CXCR3 receptors. J Immunol. 1999 Apr
1;162(7):3765-9.

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