Human Eotaxin-2/CCL24 (Recombinant)

Description

Human Eotaxin-2/CCL24
Catalog number: B2010354
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human Eotaxin-2/CCL24 expressed in E. coli. This protein acts as a chemoattractant for CCR3-bearing cells such as eosinophils, mast cells, basophils, and Th2 cells that play a role in allergic disorders.
Storage: -20C
Keywords: rHuEotaxin-2/CCL24; C-C motif chemokine 24; CK-beta-6; MPIF-2; MPIF2; SCYA24
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and
eotaxin-3/CCL26 exert differential profibrogenic effects on human lung
fibroblasts. Ann Allergy Asthma Immunol. 2010 Jan;104(1):66-72.

2: Yoshida N, Aizu-Yokota E, Sonoda Y, Moriwaki Y, Kishi K, Kasahara T.
Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic
cell line, HT93. Biol Pharm Bull. 2007 Oct;30(10):1826-32.

3: Miyagawa Y, Murakami A, Ebihara N. The proteolytic effect of mast cell
tryptase to eotaxin-1/CCL11·eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by
conjunctival fibroblasts. Jpn J Ophthalmol. 2019 Mar;63(2):215-220.

4: Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB.
Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils,
basophils, neutrophils, and macrophages as well as features of early- and late-
phase allergic reactions following cutaneous injection in human atopic and
nonatopic volunteers. J Immunol. 2002 Sep 1;169(5):2712-8.

5: Kagami S, Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Nakamura K, Takekoshi T,
Kishimoto M, Mitsui H, Torii H, Komine M, Asahina A, Tamaki K. Significant
elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in
patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the
disease activity of atopic dermatitis. Clin Exp Immunol. 2003 Nov;134(2):309-13.

6: Heiman AS, Abonyo BO, Darling-Reed SF, Alexander MS. Cytokine-stimulated
human lung alveolar epithelial cells release eotaxin-2 (CCL24) and eotaxin-3
(CCL26). J Interferon Cytokine Res. 2005 Feb;25(2):82-91.

7: Komiya A, Nagase H, Yamada H, Sekiya T, Yamaguchi M, Sano Y, Hanai N, Furuya
A, Ohta K, Matsushima K, Yoshie O, Yamamoto K, Hirai K. Concerted expression of
eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells. Cell
Immunol. 2003 Oct;225(2):91-100.

8: Schaefer D, Meyer JE, Pods R, Pethe W, Hedderich J, Schmidt C, Maune S.
Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. Int
Arch Allergy Immunol. 2006;140(3):205-14.
9: Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers
by benralizumab in patients with asthma. Respir Med. 2016 Feb;111:21-9.

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