Human CDC34 Protein

Product Description

Human CDC34 Protein
Catalog number: B2011899
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: UBCH3 protein, UBE2R1, CDC-34, CDC 34, CDC34, CDC 34 protein, CDC-34 protein, Ubiquitin-conjugating enzyme E2 R1 protein, E2-CDC34 protein, UBC3 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu HT, Liu S, Liu L, Ma RR, Gao P. EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer Cancer Res. 2018 Oct 15;78(20):5877-5890.
2: Harper JW, Schulman BA. Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis Annu Rev Biochem. 2021 Jun 20;90:403-429.
3: Choi YS, Wu K, Jeong K, Lee D, Jeon YH, Choi BS, Pan ZQ, Ryu KS, Cheong C. The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination J Biol Chem. 2010 Jun 4;285(23):17754-62.
4: Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway EMBO J. 1998 Jan 15;17(2):368-83.
5: Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ. Proximity-induced activation of human Cdc34 through heterologous dimerization Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15053-8.
6: Block K, Appikonda S, Lin HR, Bloom J, Pagano M, Yew PR. The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain Cell Cycle. 2005 Oct;4(10):1421-7.
7: Pati D, Meistrich ML, Plon SE. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis Mol Cell Biol. 1999 Jul;19(7):5001-13.
8: Butz N, Ruetz S, Natt F, Hall J, Weiler J, Mestan J, Ducarre M, Grossenbacher R, Hauser P, Kempf D, Hofmann F. The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels Exp Cell Res. 2005 Feb 15;303(2):482-93.
9: Gazdoiu S, Yamoah K, Wu K, Pan ZQ. Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains Mol Cell Biol. 2007 Oct;27(20):7041-52.
10: Block K, Boyer TG, Yew PR. Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2 J Biol Chem. 2001 Nov 2;276(44):41049-58.

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