Human BNIP1 Protein

Product Description

Human BNIP1 Protein
Catalog number: B2011642
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Vesicle transport protein SEC20 protein, NIP1 protein, SEC20 protein, TRG-8 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ryu SW, Choi K, Yoon J, Kim S, Choi C. Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner J Cell Physiol. 2012 Aug;227(8):3027-35.
2: Park J, Han JH, Myung SH, Seo YW, Kim TH. MTD-like motif of a BH3-only protein, BNIP1, induces necrosis accompanied by an intracellular calcium spike Biochem Biophys Res Commun. 2018 Jan 8;495(2):1661-1667.
3: Yasuda M, Chinnadurai G. Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1 Oncogene. 2000 May 4;19(19):2363-7.
4: Li FH, Xiang L, Ran L, Zhou S, Huang Z, Chen M, Yu WF. BNIP1 inhibits cell proliferation, migration and invasion, and promotes apoptosis by mTOR in cervical cancer cells Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1397-1407.
5: Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, Tani K, Yamamoto A, Tagaya M. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion EMBO J. 2004 Aug 18;23(16):3216-26.
6: Tang F, Wang B, Li N, Wu Y, Jia J, Suo T, Chen Q, Liu YJ, Tang J. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1 PLoS One. 2011;6(9):e24367.
7: Holling T, Bhavani GS, von Elsner L, Shah H, Kausthubham N, Bhattacharyya SS, Shukla A, Mortier GR, Schinke T, Danyukova T, Pohl S, Kutsche K, Girisha KM. A homozygous hypomorphic BNIP1 variant causes an increase in autophagosomes and reduced autophagic flux and results in a spondylo-epiphyseal dysplasia Hum Mutat. 2022 May;43(5):625-642.
8: Zhang H, Heim J, Meyhack B. Novel BNIP1 variants and their interaction with BCL2 family members FEBS Lett. 1999 Apr 1;448(1):23-7.
9: Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, Höglinger G, Müller U, Ferrari R, Hardy J, Schellenberg GD, Sleiman PM, Momeni P, Hess CP, Miller BL, Sharma M, Van Deerlin V, Smeland OB, Andreassen OA, Dale AM, Desikan RS; International Frontotemporal Dementia (FTD)–Genomics Consortium, International Collaboration for Frontotemporal Dementia, Progressive Supranuclear Palsy (PSP) Genetics Consortium, and International Parkinson’s Disease Genomics Consortium. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum JAMA Neurol. 2018 Jul 1;75(7):860-875.
10: Wang P, Wu Y, Li Y, Zheng J, Tang J. A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1 Cell Signal. 2013 Nov;25(11):2320-33.

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