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Heparin-binding EGF-like Growth Factor

$595.00 $395.00

Catalog Number: B2010304 (10 ug)
Heparin-binding EGF-like Growth Factor is a high quality research product used as highly pure Heparin-binding EGF-like Growth Factor expressed in E. coli. This protein acts as a member of the epidermal growth factor (EGF) family of growth factors that stimulate growth and differentiation. Custom bulk orders of this product are available upon request.

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SKU: B2010304 Categories: , ,

Description

Heparin-binding EGF-like Growth Factor
Catalog number: B2010304
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Heparin-binding EGF-like Growth Factor expressed in E. coli. This protein acts as a member of the epidermal growth factor (EGF) family of growth factors that stimulate growth and differentiation.
Storage: -20C
Keywords: rHuHB-EGF; HBEGF; Diphtheria toxin receptor; DTR
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kim S, Graham MJ, Lee RG, Yang L, Kim S, Subramanian V, Layne JD, Cai L,
Temel RE, Shih D, Lusis AJ, Berliner JA, Lee S. Heparin-binding EGF-like growth
factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-
associated atherosclerosis. Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):306-315.

2: Dao DT, Anez-Bustillos L, Adam RM, Puder M, Bielenberg DR. Heparin-Binding
Epidermal Growth Factor-Like Growth Factor as a Critical Mediator of Tissue
Repair and Regeneration. Am J Pathol. 2018 Nov;188(11):2446-2456.
PMC6207098.

3: Gaviglio AL, Knelson EH, Blobe GC. Heparin-binding epidermal growth factor-
like growth factor promotes neuroblastoma differentiation. FASEB J. 2017
May;31(5):1903-1915.

4: Cramer ML, Xu R, Martin PT. Soluble Heparin Binding Epidermal Growth Factor-
Like Growth Factor Is a Regulator of GALGT2 Expression and
GALGT2-Dependent Muscle and Neuromuscular Phenotypes. Mol Cell Biol. 2019
Jun 27;39(14):e00140-19.

5: Ma F, Li S, Hao H, Gao P, Dai Y, Himani C, Liu W, Gao X, Xiao X. Association
of Heparin-binding EGF-like Growth Factor Polymorphisms With Necrotizing
Enterocolitis in Preterm Infants. J Pediatr Gastroenterol Nutr. 2018
Apr;66(4):e99-e102.

6: Su Y, Luo H, Yang J. Heparin-binding EGF-like growth factor attenuates lung
inflammation and injury in a murine model of pulmonary emphysema. Growth
Factors. 2018 Dec;36(5-6):246-262.

7: Liu Z, Skafar DF, Kilburn B, Das SK, Armant DR. Extraembryonic heparin-
binding epidermal growth factor-like growth factor deficiency compromises
placentation in mice. Biol Reprod. 2019 Jan 1;100(1):217-226.

8: Raab G, Klagsbrun M. Heparin-binding EGF-like growth factor. Biochim Biophys
Acta. 1997 Dec 9;1333(3):F179-99.

9: Thönes S, Rother S, Wippold T, Blaszkiewicz J, Balamurugan K, Moeller S,
Ruiz-Gómez G, Schnabelrauch M, Scharnweber D, Saalbach A, Rademann J, Pisabarro
MT, Hintze V, Anderegg U. Hyaluronan/collagen hydrogels containing sulfated
hyaluronan improve wound healing by sustained release of heparin-binding EGF-
like growth factor. Acta Biomater. 2019 Mar 1;86:135-147.
10: Ming YC, Chao HC, Chu SM, Luo CC. Heparin-binding epidermal growth factor-
like growth factor (HB-EGF) protected intestinal ischemia-reperfusion injury
through JNK and p38/MAPK-dependent pathway for anti-apoptosis. Pediatr Neonatol.
2019 Jun;60(3):332-336.

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