Fluorogenic Caspase (Apopain) Substrate 1f-z

Product Description

Fluorogenic Caspase (Apopain) Substrate 1f-z
Catalog number: B2011408
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 821.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Caspase 3 (Apopain) Substrate 1f-z, fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Xiong C, Lu W, Zhang R, Tian M, Tong W, Gelovani J, Li C. Cell-permeable [99mTc(CO3)]-labeled fluorogenic caspase 3 substrate for dual-modality detection of apoptosis Chemistry. 2009 Sep 14;15(36):8979-84.
2: Mackay M, Pérez-López AM, Bradley M, Lilienkampf A. Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates Mol Biosyst. 2016 Mar;12(3):693-6.
3: Pérez-López AM, Soria-Gila ML, Marsden ER, Lilienkampf A, Bradley M. Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells PLoS One. 2016 May 11;11(5):e0153209.
4: Lee BW, Johnson GL, Hed SA, Darzynkiewicz Z, Talhouk JW, Mehrotra S. DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet Biotechniques. 2003 Nov;35(5):1080-5.
5: Kitevska T, Roberts SJ, Pantaki-Eimany D, Boyd SE, Scott FL, Hawkins CJ. Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate Biosci Rep. 2014 Apr 1;34(2):e00100.
6: Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells Cell Death Differ. 2019 Dec;26(12):2695-2709.
7: He L, Ye S, Fang J, Zhang Y, Cui C, Wang A, Zhao Y, Shi H. Real-Time Visualization of Embryonic Apoptosis Using a Near-Infrared Fluorogenic Probe for Embryo Development Evaluation Anal Chem. 2021 Sep 7;93(35):12122-12130.
8: Castro MM, Fuah J, Ali M, Sung M, Schulz J, Kondo MY, Fan X, Holt A, Schulz R. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2 Biochem Pharmacol. 2013 Aug 15;86(4):469-75.
9: Fuente-Garcia C, Sentandreu E, Aldai N, Sentandreu MA. Optimization of a fluorogenic assay to determine caspase 3/7 activity in meat extracts Food Sci Technol Int. 2022 Mar;28(2):128-134.
10: Peterson QP, Goode DR, West DC, Botham RC, Hergenrother PJ. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis Nat Protoc. 2010 Feb;5(2):294-302.

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