Fatty Acid Desaturase 2 Human Recombinant

Product Description

Fatty Acid Desaturase 2 Human Recombinant
Catalog number: B2017397
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 300 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: Acyl-CoA (8-3)-Desaturase, FADS1, Δ5 Fatty Acid Desaturase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Leone P, Quarta S, Tolomeo M, Barile M. Purification of Recombinant Human 6His-FAD Synthase (Isoform 2) and Quantitation of FAD/Protein Monomer Ratio by UV-Vis Spectra Methods Mol Biol. 2021;2280:69-85.
2: Leone P, Galluccio M, Brizio C, Barbiroli A, Iametti S, Indiveri C, Barile M. The hidden side of the human FAD synthase 2 Int J Biol Macromol. 2019 Oct 1;138:986-995.
3: Galluccio M, Indiveri C. Heterologous Overexpression of Human FAD Synthase Isoforms 1 and 2 Methods Mol Biol. 2021;2280:55-67.
4: Schübel R, Jaudszus A, Krüger R, Roth A, Klempt M, Barth SW. Dietary essential α-linolenic acid and linoleic acid differentially modulate TNFα-induced NFκB activity in FADS2-deficient HEK-293 cells Int J Food Sci Nutr. 2017 Aug;68(5):553-559.
5: Torchetti EM, Bonomi F, Galluccio M, Gianazza E, Giancaspero TA, Iametti S, Indiveri C, Barile M. Human FAD synthase (isoform 2): a component of the machinery that delivers FAD to apo-flavoproteins FEBS J. 2011 Nov;278(22):4434-49.
6: Park WJ, Kothapalli KS, Lawrence P, Brenna JT. FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids PLoS One. 2011;6(11):e28186.
7: Wang GJ, Tian Y, Zhang HY. [Research Progress of Fatty Acid Desaturase 2 Gene in Glycolipid Metabolism] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Feb;44(1):158-163.
8: Vila IK, Chamma H, Steer A, Saccas M, Taffoni C, Turtoi E, Reinert LS, Hussain S, Marines J, Jin L, Bonnefont X, Hubert M, Schwartz O, Paludan SR, Van Simaeys G, Doumont G, Sobhian B, Vlachakis D, Turtoi A, Laguette N. STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses Cell Metab. 2022 Jan 4;34(1):125-139.e8.
9: Yamane D, Hayashi Y, Matsumoto M, Nakanishi H, Imagawa H, Kohara M, Lemon SM, Ichi I. FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication Cell Chem Biol. 2022 May 19;29(5):799-810.e4.
10: Shockey J, Gilbert MK, Thyssen GN. A mutant cotton fatty acid desaturase 2-1d allele causes protein mistargeting and altered seed oil composition BMC Plant Biol. 2023 Mar 17;23(1):147.

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