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Fak Ligand (Highly Pure)

$795.00

Catalog Number: B2012543 (1 mg)
Fak Ligand (Highly Pure) is a high quality extracellular domain of the human Fak receptor. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2012543 Categories: , Tag:

Description

Fak Ligand (Highly Pure)
Catalog number: B2012543
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 583.6 g/mol
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Fak ligand linker conjugate 1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Silvestris F, Nagata S, Cafforio P, Silvestris N, Dammacco F. Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients J Exp Med. 1996 Dec 1;184(6):2287-300.
2: Ramaswamy M, Dumont C, Cruz AC, Muppidi JR, Gomez TS, Billadeau DD, Tybulewicz VL, Siegel RM. Cutting edge: Rac GTPases sensitize activated T cells to die via Fas J Immunol. 2007 Nov 15;179(10):6384-8.
3: Wong Fok Lung T, Giogha C, Creuzburg K, Ong SY, Pollock GL, Zhang Y, Fung KY, Pearson JS, Hartland EL. Mutagenesis and Functional Analysis of the Bacterial Arginine Glycosyltransferase Effector NleB1 from Enteropathogenic Escherichia coli Infect Immun. 2016 Apr 22;84(5):1346-1360.
4: Wong DS, Li J, Yan X, Wang B, Li R, Zhang L, Bian L. Magnetically Tuning Tether Mobility of Integrin Ligand Regulates Adhesion, Spreading, and Differentiation of Stem Cells Nano Lett. 2017 Mar 8;17(3):1685-1695.
5: Ou-Yang CW, Zhu M, Fuller DM, Sullivan SA, Chuck MI, Ogden S, Li QJ, Zhang W. Role of LAT in the granule-mediated cytotoxicity of CD8 T cells Mol Cell Biol. 2012 Jul;32(14):2674-84.
6: Motoki K, Mori E, Matsumoto A, Thomas M, Tomura T, Humphreys R, Albert V, Muto M, Yoshida H, Aoki M, Tamada T, Kuroki R, Yoshida H, Ishida I, Ware CF, Kataoka S. Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 Clin Cancer Res. 2005 Apr 15;11(8):3126-35.
7: Kim WS, Lee KS, Kim JH, Kim CK, Lee G, Choe J, Won MH, Kim TH, Jeoung D, Lee H, Kim JY, Ae Jeong M, Ha KS, Kwon YG, Kim YM. The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production Free Radic Biol Med. 2017 Nov;112:567-577.
8: Kaminski M, Kiessling M, Süss D, Krammer PH, Gülow K. Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death Mol Cell Biol. 2007 May;27(10):3625-39.
9: Zhu JY, Giaisi M, Köhler R, Müller WW, Mühleisen A, Proksch P, Krammer PH, Li-Weber M. Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression Cell Death Differ. 2009 Sep;16(9):1289-99.
10: Kondo T, Takeuchi K, Doi Y, Yonemura S, Nagata S, Tsukita S. ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis J Cell Biol. 1997 Nov 3;139(3):749-58.

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