DNA-Dependent Protein Kinase

Product Description

DNA-Dependent Protein Kinase
Catalog number: B2016334
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 U
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: DNA-Dependent Protein Kinase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lee YR, Kang GS, Oh T, Jo HJ, Park HJ, Ahn GO. DNA_Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair Mol Cells. 2023 Apr 30;46(4):200-205.
2: Sui J, Zhang S, Chen BPC. DNA_dependent protein kinase in telomere maintenance and protection Cell Mol Biol Lett. 2020 Jan 17;25:2.
3: George VC, Ansari SA, Chelakkot VS, Chelakkot AL, Chelakkot C, Menon V, Ramadan W, Ethiraj KR, El-Awady R, Mantso T, Mitsiogianni M, Panagiotidis MI, Dellaire G, Vasantha Rupasinghe HP. DNA_dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer Mutat Res Rev Mutat Res. 2019 Apr-Jun;780:92-105.
4: Yang Y, Liu S, Wang P, Ouyang J, Zhou N, Zhang Y, Huang S, Jia Z, Zhang A. DNA_dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice Nat Commun. 2023 Mar 11;14(1):1334.
5: Jackson SP. DNA_dependent protein kinase Int J Biochem Cell Biol. 1997 Jul;29(7):935-8.
6: Kurosawa A. Autophosphorylation and Self-Activation of DNA_Dependent Protein Kinase Genes (Basel). 2021 Jul 19;12(7):1091.
7: Wang L, Wu L, Du Y, Wang X, Yang B, Guo S, Zhou Y, Xu Y, Yang S, Zhang Y, Ren J. DNA_dependent protein kinase catalytic subunit (DNA-PKcs) drives angiotensin II-induced vascular remodeling through regulating mitochondrial fragmentation Redox Biol. 2023 Nov;67:102893.
8: Liang S, Blundell TL. Human DNA-dependent protein kinase activation mechanism Nat Struct Mol Biol. 2023 Feb;30(2):140-147.
9: Matsumoto Y, Asa ADDC, Modak C, Shimada M. DNA_Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated Genes (Basel). 2021 Jul 27;12(8):1143.
10: Harnor SJ, Brennan A, Cano C. Targeting DNA-Dependent Protein Kinase for Cancer Therapy ChemMedChem. 2017 Jun 21;12(12):895-900.

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