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Cardiotrophin-1 (Human, Recombinant)

$695.00 $495.00

Catalog Number: B2010349 (10 ug)
Cardiotrophin-1 (Human, Recombinant) is a high quality research product used as highly pure Cardiotrophin-1 (Human, Recombinant) expressed in CHO. This protein acts as a member of the IL-6 family of cytokines and a key regulator of energy homeostasis and of glucose and lipid metabolism. Custom bulk orders of this product are available upon request.

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SKU: B2010349 Categories: , ,

Description

Cardiotrophin-1 (Human, Recombinant)
Catalog number: B2010349
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Cardiotrophin-1 (Human, Recombinant) expressed in CHO. This protein acts as a member of the IL-6 family of cytokines and a key regulator of energy homeostasis and of glucose and lipid metabolism.
Storage: -20C
Keywords: rHuCT-1; CTF1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López
B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G,
Moreno MU, Jaisser F, Díez J, González A, López-Andrés N. CT-1
(Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.
Hypertension. 2019 Mar;73(3):602-611.

2: Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-
Quintela A, Martínez JA, Moreno-Aliaga MJ, Portillo MP. Role of Omentin, Vaspin,
Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J
Mol Sci. 2017 Aug 15;18(8):1770.

3: Miteva K, Baptista D, Montecucco F, Asrih M, Burger F, Roth A, Fraga-Silva
RA, Stergiopulos N, Mach F, Brandt KJ. Cardiotrophin-1 Deficiency Abrogates
Atherosclerosis Progression. Sci Rep. 2020 Apr 1;10(1):5791.

4: López-Yoldi M, Moreno-Aliaga MJ, Bustos M. Cardiotrophin-1: A multifaceted
cytokine. Cytokine Growth Factor Rev. 2015 Oct;26(5):523-32.

5: Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín
JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.
Cardiotrophin_1 opposes renal fibrosis in mice: Potential prevention of chronic
kidney disease. Acta Physiol (Oxf). 2019 Jun;226(2):e13247.

6: Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-
Sánchez E, López-Montañés D, Quiros Y, López-Hernández FJ, Rodríguez-Pérez A,
López-Novoa JM. Cardiotrophin-1 attenuates experimental colitis in mice. Clin
Sci (Lond). 2018 May 23;132(9):985-1001.
7: Carneros D, Santamaría EM, Larequi E, Vélez-Ortiz JM, Reboredo M, Mancheño U,
Perugorria MJ, Navas P, Romero-Gómez M, Prieto J, Hervás-Stubbs S, Bustos M.
Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2
macrophage polarization. FASEB J. 2019 Jun;33(6):7578-7587.

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