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Biotinylated Mononucleosomes (H2A.Bbd)

Original price was: $2,195.00.Current price is: $1,095.00.

Catalog Number: B2016683 (10 µg)
Biotinylated Mononucleosomes (H2A.Bbd) is a high quality specialized protein complexes that consist of DNA wrapped around histone proteins. These complexes are modified with biotin, a small molecule that can be used for various research purposes. Biotinylated Mononucleosomes (H2A.Bbd) are commonly used in biochemical and biophysical studies to investigate chromatin structure, gene regulation, and protein-DNA interactions. They can also be utilized in assays to study epigenetic modifications and chromatin remodeling processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

Biotinylated Mononucleosomes (H2A.Bbd)
Catalog number: B2016683
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: ~107 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: H2A.Bbd
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Wang D, Hara R, Singh G, Sancar A, Lippard SJ. Nucleotide excision repair from site-specifically platinum-modified nucleosomes Biochemistry. 2003 Jun 10;42(22):6747-53.
2: Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus EMBO J. 1998 Oct 15;17(20):5974-86.
3: Lantermann A, Strålfors A, Fagerström-Billai F, Korber P, Ekwall K. Genome-wide mapping of nucleosome positions in Schizosaccharomyces pombe Methods. 2009 Jul;48(3):218-25.
4: Kizaki S, Zou T, Li Y, Han YW, Suzuki Y, Harada Y, Sugiyama H. Preferential 5-Methylcytosine Oxidation in the Linker Region of Reconstituted Positioned Nucleosomes by Tet1 Protein Chemistry. 2016 Nov 7;22(46):16598-16601.
5: Vaughan RM, Dickson BM, Whelihan MF, Johnstone AL, Cornett EM, Cheek MA, Ausherman CA, Cowles MW, Sun ZW, Rothbart SB. Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1 Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8775-8780.
6: Vaughan RM, Dickson BM, Cornett EM, Harrison JS, Kuhlman B, Rothbart SB. Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance Nucleic Acids Res. 2018 May 18;46(9):4405-4416.
7: Martin C, Cao R, Zhang Y. Substrate preferences of the EZH2 histone methyltransferase complex J Biol Chem. 2006 Mar 31;281(13):8365-70.
8: Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL. Histone H4-K16 acetylation controls chromatin structure and protein interactions Science. 2006 Feb 10;311(5762):844-7.
9: Mullahoo J, Zhang T, Clauser K, Carr SA, Jaffe JD, Papanastasiou M. Dual protease type XIII/pepsin digestion offers superior resolution and overlap for the analysis of histone tails by HX-MS Methods. 2020 Dec 1;184:135-140.
10: Tóth K, Brun N, Langowski J. Chromatin compaction at the mononucleosome level Biochemistry. 2006 Feb 14;45(6):1591-8.

Products Related to Biotinylated Mononucleosomes (H2A.Bbd) can be found at Proteins

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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