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Betacellulin (Human, Recombinant)

$395.00

Catalog Number: B2010295 (10 ug)
Betacellulin (Human, Recombinant) is a high quality research product used as highly pure Betacellulin (Human, Recombinant) expressed in E. coli. This protein acts as a glycoprotein that improves glucose tolerance by increasing β-cell differentiation and regeneration from ductal and/or acinar cells. Custom bulk orders of this product are available upon request.

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SKU: B2010295 Categories: ,

Description

Betacellulin (Human, Recombinant)
Catalog number: B2010295
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Betacellulin (Human, Recombinant) expressed in E. coli. This protein acts as a glycoprotein that improves glucose tolerance by increasing β-cell differentiation and regeneration from ductal and/or acinar cells.
Storage: -20C
Keywords: rHuBetacellulin; Probetacellulin; BTC
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zhao J, Klausen C, Yi Y, Cheng JC, Chang HM, Leung PCK. Betacellulin enhances
ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling.
Cell Signal. 2020 Jan;65:109439.

2: Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat
KM, Bivona TG, Weiss WA. Betacellulin drives therapy resistance in glioblastoma.
Neuro Oncol. 2020 Apr 15;22(4):457-469.

3: Roskoski R Jr. The ErbB/HER family of protein-tyrosine kinases and cancer.
Pharmacol Res. 2014 Jan;79:34-74.

4: Rush JS, Peterson JL, Ceresa BP. Betacellulin (BTC) Biases the EGFR To
Dimerize with ErbB3. Mol Pharmacol. 2018 Dec;94(6):1382-1390.

5: Hedegger K, Stumpf F, Blum H, Graf A, Schmid RM, Lesina M, Algül H, Schneider
MR, Dahlhoff M. The protective effect of betacellulin against acute pancreatitis
is ERBB4 dependent. J Gastroenterol. 2020 Mar;55(3):317-329.

6: Dahlhoff M, Wolf E, Schneider MR. The ABC of BTC: structural properties and
biological roles of betacellulin. Semin Cell Dev Biol. 2014 Apr;28:42-8.

7: Singh B, Carpenter G, Coffey RJ. EGF receptor ligands: recent advances.
F1000Res. 2016 Sep 8;5:F1000 Faculty Rev-2270.

8: Zhao J, Klausen C, Qiu X, Cheng JC, Chang HM, Leung PC. Betacellulin induces
Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer
cells. Oncotarget. 2016 May 17;7(20):28881-90.

9: Chatterton DE, Nguyen DN, Bering SB, Sangild PT. Anti-inflammatory mechanisms
of bioactive milk proteins in the intestine of newborns. Int J Biochem Cell
Biol. 2013 Aug;45(8):1730-47. doi: 10.1016/j.biocel.2013.04.028. Epub 2013 May
6. PMID: 23660296.
10: Sugimoto M, Cutler A, Grossman G, Anand-Apte B. Regulation of retinal
vascular permeability by betacellulin. Adv Exp Med Biol. 2012;723:293-8.

Products Related to Betacellulin (Human, Recombinant) : Proteins

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