Benzyl α-D-GlcNAc (Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside)
Original price was: $795.00.$395.00Current price is: $395.00.
Catalog Number: B2027231 (1 g)
Benzyl α-D-GlcNAc (Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside) is a synthetic glycoside derivative widely utilized in glycobiology research as an inhibitor of mucin-type O-glycan biosynthesis. By acting as a competitive substrate or inhibitor for specific glycosyltransferases, it allows researchers to study carbohydrate processing, cellular adhesion, and glycoprotein function. Supplied as a high-purity biochemical reagent, this product is ideal for cell culture applications, enzymatic assays, and metabolic studies. Custom bulk amounts of this product are available upon request.
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Product Description
Benzyl α-D-GlcNAc (Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside)
Catalog number: B2027231
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 311.34
Supplied as: Powder
Storage: NA
Keywords: Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside, Benzyl N-acetyl-α-D-glucosaminide, Benzyl-α-GlcNAc
References:
1. Kuan SF, Byrd JC, Basbaum C, Kim YS. Inhibition of mucin synthesis by aryl N-acetyl-alpha-D-galactosaminides in human colon cancer cells. Journal of Biological Chemistry. 1989;264(32):19271-19277.
2. Huet G, Hennebicq-Reig S, de Bolos C, et al. GalNAc-alpha-O-benzyl inhibits NeuAc alpha 2-3 glycosylation and blocks the intracellular transport of apical glycoproteins and mucus in differentiated HT-29 cells. Journal of Cell Biology. 1995;130(2):331-346.
3. Delannoy P, Kim I, Emery N, et al. Glycosylation inhibition by benzyl-alpha-GalNAc in human colon carcinoma cells. Glycobiology. 1996;6(5):543-550.
4. Gouyer V, Leteurtre E, Zanetta JP, et al. Inhibition of O-glycosylation by benzyl-alpha-GalNAc alters the secretion and mucosal distribution of apical glycoproteins. Journal of Cellular Biochemistry. 2001;81(1):127-138.
5. Huang J, Byrd JC, Yoon WH, Kim YS. Effect of benzyl-alpha-GalNAc on oncofetal fibronectin expression and O-glycosylation in cancer cells. International Journal of Cancer. 1992;52(6):978-985.
6. Ulloa F, Real FX. Effects of O-glycosylation inhibition by benzyl-alpha-GalNAc on cell surface expression of mucin-type glycoproteins. Biochemical Journal. 2000;350(1):269-277.
7. Hennebicq-Reig S, Huet G, Kim I, et al. O-glycosylation inhibition by benzyl-alpha-GalNAc induces vesicular accumulation of apical proteins in HT-29 cells. Experimental Cell Research. 1998;241(2):374-386.
8. Patsos G, Corfield A. O-glycan biosynthesis and its inhibition by synthetic benzyl-alpha-GalNAc derivatives in intestinal epithelium. Biochimica et Biophysica Acta. 2009;1790(9):910-920.
9. Brockhausen I, Schutzbach J, Kuhns W. Glycoproteins and glycosyltransferases: inhibition of O-glycan elongation by synthetic aryl glycosides. Acta Anatomica. 1998;161(1-4):36-56.
10. Wandall HH, Hassan H, Mirgorodskaya E, et al. Substrate toxicities and glycosylation alterations induced by benzyl-alpha-GalNAc in human tumor cells. Journal of Biological Chemistry. 1997;272(37):23503-23514.
Benzyl α-D-GlcNAc (Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside)
Products Related to Benzyl α-D-GlcNAc (Benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside) can be found at Carbohydrates
Additional Information
| Weight | 0.15 oz |
|---|---|
| Dimensions | 2 × 0.5 × 0.5 in |
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